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Evidence of increased exposure to Toxoplasma gondii in individuals with recent onset psychosis but not with established schizophrenia

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  • Robert Yolken
  • E Fuller Torrey
  • Faith Dickerson

Abstract

A possible role for Toxoplasma gondii in the etiopathogenesis of schizophrenia is supported by epidemiological studies and animal models of infection. However, recent studies attempting to link Toxoplasma to schizophrenia have yielded mixed results. We performed a nested case-control study measured serological evidence of exposure to Toxoplasma gondii in a cohort of 2052 individuals. Within this cohort, a total of 1481 individuals had a psychiatric disorder and 571 of were controls without a psychiatric disorder. We found an increased odds of Toxoplasma exposure in individuals with a recent onset of psychosis (OR 2.44, 95% Confidence Interval 1.4–4.4, p

Suggested Citation

  • Robert Yolken & E Fuller Torrey & Faith Dickerson, 2017. "Evidence of increased exposure to Toxoplasma gondii in individuals with recent onset psychosis but not with established schizophrenia," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 11(11), pages 1-10, November.
  • Handle: RePEc:plo:pntd00:0006040
    DOI: 10.1371/journal.pntd.0006040
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    Cited by:

    1. Tooran Nayeri Chegeni & Mehdi Sharif & Shahabeddin Sarvi & Mahmood Moosazadeh & Mahbobeh Montazeri & Sargis A Aghayan & Nader Jafari Balalami & Shirzad Gholami & Zahra Hosseininejad & Reza Saberi & Da, 2019. "Is there any association between Toxoplasma gondii infection and depression? A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-17, June.

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