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Effectiveness of 32 versus 20 weeks of prednisolone in leprosy patients with recent nerve function impairment: A randomized controlled trial

Author

Listed:
  • Inge Wagenaar
  • Erik Post
  • Wim Brandsma
  • Bob Bowers
  • Khorshed Alam
  • Vanaja Shetty
  • Vivek Pai
  • Sajid Husain
  • Cita Rosita Sigit Prakoeswa
  • Linda Astari
  • Deanna Hagge
  • Mahesh Shah
  • Kapil Neupane
  • Krishna Bahadur Tamang
  • The TENLEP study group
  • Peter Nicholls
  • Jan Hendrik Richardus

Abstract

Background: While prednisolone is commonly used to treat recent nerve function impairment (NFI) in leprosy patients, the optimal treatment duration has not yet been established. In this “Treatment of Early Neuropathy in Leprosy” (TENLEP) trial, we evaluated whether a 32-week prednisolone course is more effective than a 20-week course in restoring and improving nerve function. Methods: In this multi-centre, triple-blind, randomized controlled trial, leprosy patients who had recently developed clinical NFI (

Suggested Citation

  • Inge Wagenaar & Erik Post & Wim Brandsma & Bob Bowers & Khorshed Alam & Vanaja Shetty & Vivek Pai & Sajid Husain & Cita Rosita Sigit Prakoeswa & Linda Astari & Deanna Hagge & Mahesh Shah & Kapil Neupa, 2017. "Effectiveness of 32 versus 20 weeks of prednisolone in leprosy patients with recent nerve function impairment: A randomized controlled trial," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 11(10), pages 1-18, October.
    • Handle: RePEc:plo:pntd00:0005952
    DOI: 10.1371/journal.pntd.0005952
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