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A clinical severity scoring system for visceral leishmaniasis in immunocompetent patients in South Sudan

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  • Suzette S Kämink
  • Simon M Collin
  • Tim Harrison
  • Francis Gatluak
  • Abdul Wasay Mullahzada
  • Koert Ritmeijer

Abstract

Background: South Sudan is one of the most endemic countries for visceral leishmaniasis (VL), and is frequently affected by large epidemics. In resource-limited settings, clinicians require a simple clinical tool to identify VL patients who are at increased risk of dying, and who need specialised treatment with liposomal amphotericin B and other supportive care. The aim of this study was to develop and validate a clinical severity scoring system based on risk factors for death in VL patients in South Sudan. Methods: A retrospective analysis was conducted of data from a cohort of 6,633 VL patients who were treated in the Médecins Sans Frontières (MSF) hospital in Lankien between July 2013 and June 2015. Risk factors for death during treatment were identified using multivariable logistic regression models, and the regression coefficients were used to develop a severity scoring system. Sensitivity and specificity of score cut-offs were assessed by receiver operating characteristic (ROC) analysis. Results: In multivariable models, risk factors for death in adult VL patients were: anaemia (odds ratio (OR) 4.46 (95% CI 1.58–12.6) for Hb

Suggested Citation

  • Suzette S Kämink & Simon M Collin & Tim Harrison & Francis Gatluak & Abdul Wasay Mullahzada & Koert Ritmeijer, 2017. "A clinical severity scoring system for visceral leishmaniasis in immunocompetent patients in South Sudan," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 11(10), pages 1-15, October.
    • Handle: RePEc:plo:pntd00:0005921
    DOI: 10.1371/journal.pntd.0005921
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    Cited by:

    1. Charles Abongomera & Saskia van Henten & Florian Vogt & Jozefien Buyze & Kristien Verdonck & Johan van Griensven, 2020. "Prognostic factors for mortality among patients with visceral leishmaniasis in East Africa: Systematic review and meta-analysis," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(5), pages 1-19, May.

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