The disease burden of human cystic echinococcosis based on HDRs from 2001 to 2014 in Italy

Background: Cystic echinococcosis (CE) is an important neglected zoonotic parasitic infection belonging to the subgroup of seven Neglected Zoonotic Disease (NZDs) included in the World Health Organization’s official list of 18 Neglected Tropical Diseases (NTDs). CE causes serious global human health concerns and leads to significant economic losses arising from the costs of medical treatment, morbidity, life impairments and fatality rates in human cases. Moreover, CE is endemic in several Italian Regions. The aim of this study is to perform a detailed analysis of the economic burden of hospitalization and treatment costs and to estimate the Disability Adjusted Life Years (DALYs) of CE in Italy. Methods and findings: In the period from 2001 to 2014, the direct costs of 21,050 Hospital Discharge Records (HDRs) belonging to 12,619 patients with at least one CE-related diagnosis codes were analyzed in order to quantify the economic burden of CE. CE cases average per annum are 901 (min—max = 480–1,583). Direct costs include expenses for hospitalizations, medical and surgical treatment incurred by public and private hospitals and were computed on an individual basis according to Italian Health Ministry legislation. Moreover, we estimated the DALYs for each patient. The Italian financial burden of CE is around € 53 million; the national average economic burden per annum is around € 4 million; the DALYs of the population from 2001 to 2014 are 223.35 annually and 5.26 DALYs per 105 inhabitants. Conclusion: In Italy, human CE is responsible for significant economic losses in the public health sector. In humans, costs associated with CE have been shown to have a great impact on affected individuals, their families and the community as a whole. This study could be used as a tool to prioritize and make decisions with regard to a surveillance system for this largely preventable yet neglected disease. It demonstrates the need of implementing a CE control program aimed at preventing the considerable economic and social losses it causes in high incidence areas. Author summary: CE is a neglected tropical disease that remains a considerable health problem in endemic regions and which leads to substantial economic losses for agriculture sectors and public health systems. The parasitic cycle requires a definitive host (canidae) and an intermediate host (livestock species), while humans are only occasionally hosts. CE is more prevalent in areas where extensive or semi-extensive farming of livestock (mostly sheep) is common. The study of prevalence and health expenditure at the national macro-regional and regional level is a prerequisite for creating awareness of the importance of this disease. The Italian Ministry of Health provides remuneration to its regions’ hospitals for treatment of illnesses. In this study 21,050 hospital discharge records with CE diagnosis from 2001 to 2014 related to 12,619 patients were analyzed. The median of CE hospitalizations per annum was 848. The direct costs of HDRs for echinococcosis were estimated to be € 53,175,934.34. The assessment of economic remuneration by Italian Regions grouped by Nomenclature of Territorial Units 1 (NUTS1) shows that Southern Italy and its major islands spent €13,523,999 and €15,171,739 respectively. The national annual average direct cost for 105 inhabitants was € 6,398. The study of the National DALYs, a measure of social burden of disease, shows that 41% was correlated to Island patients DALYs per annum are 223.4. An analysis of direct costs and an estimate of DALYs are key factors for establishing how to prioritize control measures for CE, which is essentially a preventable disease.