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Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease

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  • Mary-Anne Hartley
  • Alyssa Young
  • Anh-Minh Tran
  • Harry Henry Okoni-Williams
  • Mohamed Suma
  • Brooke Mancuso
  • Ahmed Al-Dikhari
  • Mohamed Faouzi

Abstract

Background: Despite the notoriety of Ebola virus disease (EVD) as one of the world’s most deadly infections, EVD has a wide range of outcomes, where asymptomatic infection may be almost as common as fatality. With increasingly sensitive EVD diagnosis, there is a need for more accurate prognostic tools that objectively stratify clinical severity to better allocate limited resources and identify those most in need of intensive treatment. Methods/Principal Findings: This retrospective cohort study analyses the clinical characteristics of 158 EVD(+) patients at the GOAL-Mathaska Ebola Treatment Centre, Sierra Leone. The prognostic potential of each characteristic was assessed and incorporated into a statistically weighted disease score. The mortality rate among EVD(+) patients was 60.8% and highest in those aged 25 years (p

Suggested Citation

  • Mary-Anne Hartley & Alyssa Young & Anh-Minh Tran & Harry Henry Okoni-Williams & Mohamed Suma & Brooke Mancuso & Ahmed Al-Dikhari & Mohamed Faouzi, 2017. "Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 11(2), pages 1-20, February.
    • Handle: RePEc:plo:pntd00:0005265
    DOI: 10.1371/journal.pntd.0005265
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