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Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy

Author

Listed:
  • Gabrielle Debacq
  • Luz M Moyano
  • Héctor H Garcia
  • Farid Boumediene
  • Benoit Marin
  • Edgard B Ngoungou
  • Pierre-Marie Preux

Abstract

Background: We reviewed studies that analyzed cysticercosis (CC), neurocysticercosis (NCC) and epilepsy across Latin America, Asia and Sub-Saharan Africa, to estimate the odds ratio and etiologic fraction of epilepsy due to CC in tropical regions. Methodology: We conducted a systematic review of the literature on cysticercosis and epilepsy in the tropics, collecting data from case-control and cross-sectional studies. Exposure criteria for CC included one or more of the following: serum ELISA or EITB positivity, presence of subcutaneous cysts (both not verified and unverified by histology), histology consistent with calcified cysts, and brain CT scan consistent with NCC. A common odds-ratio was then estimated using meta-analysis. Principal findings: 37 studies from 23 countries were included (n = 24,646 subjects, 14,934 with epilepsy and 9,712 without epilepsy). Of these, 29 were case-control (14 matched). The association between CC and epilepsy was significant in 19 scientific articles. Odds ratios ranged from 0.2 to 25.4 (a posteriori power 4.5–100%) and the common odds ratio was 2.7 (95% CI 2.1–3.6, p

Suggested Citation

  • Gabrielle Debacq & Luz M Moyano & Héctor H Garcia & Farid Boumediene & Benoit Marin & Edgard B Ngoungou & Pierre-Marie Preux, 2017. "Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 11(3), pages 1-17, March.
    • Handle: RePEc:plo:pntd00:0005153
    DOI: 10.1371/journal.pntd.0005153
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