Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review

Background: Fascioliasis has been sporadically associated with chronic liver disease on previous studies. In order to describe the current evidence, we carried out a systematic review to assess the association between fascioliasis with liver fibrosis, cirrhosis and cancer. Methodology and Principal Findings: A systematic search of electronic databases (PubMed, LILACS, Scopus, Embase, Cochrane, and Scielo) was conducted from June to July 2015 and yielded 1,557 published studies. Among 21 studies that met inclusion and exclusion criteria, 12 studies explored the association of F. hepatica with liver fibrosis, 4 with liver cirrhosis, and 5 with cancer. Globally these studies suggested the ability of F. hepatica to promote liver fibrosis and cirrhosis. The role of F. hepatica in cancer is unknown. Given the heterogeneity of the studies, a meta-analysis could not be performed. Conclusions: Future high-quality studies are needed to determine the role of F. hepatica on the development of liver fibrosis, liver cirrhosis, and cancer in humans. Author Summary: Fascioliasis is a neglected infectious disease caused by the trematode Fasciola. This parasite (liver fluke) is endemic in many parts of the world including countries from Asia, Africa, Europe and the Americas. High prevalence rates of fascioliasis has been repeatedly reported in the Andean region of South America. Liver complications in infected humans by this fluke have been sporadically reported in the literature. For instance, the relationship between F. hepatica infection and liver fibrosis has been suggested but its association with cancer is unclear. In this study, we found some evidence of an association between Fasciola infection with liver fibrosis and cirrhosis, but little between Fasciola and cancer. As Fasciola is highly endemic in some regions of the developing world, our study shed light on the complications of this parasitic infection which are not that different from flukes such as Schistosoma or Opisthorchis. We believe that further investigations are needed in order to elucidate the pathways in how F. hepatica infection causes liver damage.