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Risk Factors for Disseminated Histoplasmosis in a Cohort of HIV-Infected Patients in French Guiana

Author

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  • Mathieu Nacher
  • Antoine Adenis
  • Denis Blanchet
  • Vincent Vantilcke
  • Magalie Demar
  • Célia Basurko
  • Emilie Gaubert-Maréchal
  • Julie Dufour
  • Christine Aznar
  • Bernard Carme
  • Pierre Couppié

Abstract

Disseminated histoplasmosis is the first AIDS-defining infection in French Guiana. A retrospective cohort study studied predictive factors of disseminated histoplasmosis in HIV-infected patients between 1996 and 2008. Cox proportional hazards models were used. The variables studied were age, sex, last CD4/CD8 count, CD4 nadir, herpes or pneumocystosis, cotrimoxazole and fluconazole use, antiretroviral treatment and the notion of recent initiation of HAART. A total of 1404 patients were followed for 6833 person-years. The variables independently associated with increased incidence of disseminated histoplasmosis were CD4 count

Suggested Citation

  • Mathieu Nacher & Antoine Adenis & Denis Blanchet & Vincent Vantilcke & Magalie Demar & Célia Basurko & Emilie Gaubert-Maréchal & Julie Dufour & Christine Aznar & Bernard Carme & Pierre Couppié, 2014. "Risk Factors for Disseminated Histoplasmosis in a Cohort of HIV-Infected Patients in French Guiana," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 8(1), pages 1-7, January.
    • Handle: RePEc:plo:pntd00:0002638
    DOI: 10.1371/journal.pntd.0002638
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