IDEAS home Printed from https://ideas.repec.org/a/plo/pntd00/0002480.html
   My bibliography  Save this article

Epilepsy and Neurocysticercosis in Latin America: A Systematic Review and Meta-analysis

Author

Listed:
  • Elisa Bruno
  • Alessandro Bartoloni
  • Lorenzo Zammarchi
  • Marianne Strohmeyer
  • Filippo Bartalesi
  • Javier A Bustos
  • Saul Santivañez
  • Héctor H García
  • Alessandra Nicoletti
  • the COHEMI Project Study Group

Abstract

Background: The difference in epilepsy burden existing among populations in tropical regions has been attributed to many factors, including the distribution of infectious diseases with neurologic sequels. To define the burden of epilepsy in Latin American Countries (LAC) and to investigate the strength of association with neurocysticercosis (NCC), considered one of the leading causes of epilepsy, we performed a systematic review and meta-analysis of the literature. Methodology: Studies published until 2012 were selected applying predefined inclusion criteria. Lifetime epilepsy (LTE) prevalence, active epilepsy (AE) prevalence, incidence, mortality, treatment gap (TG) and NCC proportion among people with epilepsy (PWE) were extracted. Median values were obtained for each estimate using random effects meta-analysis. The impact of NCC prevalence on epilepsy estimates was determined using meta-regression models. To assess the association between NCC and epilepsy, a further meta-analysis was performed on case-control studies. Principal findings: The median LTE prevalence was 15.8/1,000 (95% CI 13.5–18.3), the median AE prevalence was 10.7/1,000 (95% CI 8.4–13.2), the median incidence was 138.2/100,000 (95% CI 83.6–206.4), the overall standardized mortality ratio was 1.4 (95% CI 0.01–6.1) and the overall estimated TG was 60.6% (95% CI 45.3–74.9). The median NCC proportion among PWE was 32.3% (95% CI 26.0–39.0). Higher TG and NCC estimates were associated with higher epilepsy prevalence. The association between NCC and epilepsy was significant (p

Suggested Citation

  • Elisa Bruno & Alessandro Bartoloni & Lorenzo Zammarchi & Marianne Strohmeyer & Filippo Bartalesi & Javier A Bustos & Saul Santivañez & Héctor H García & Alessandra Nicoletti & the COHEMI Project Study, 2013. "Epilepsy and Neurocysticercosis in Latin America: A Systematic Review and Meta-analysis," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 7(10), pages 1-11, October.
    • Handle: RePEc:plo:pntd00:0002480
    DOI: 10.1371/journal.pntd.0002480
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002480
    Download Restriction: no
    File URL: https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002480&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pntd.0002480?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Maria Anauati & Sebastian Galiani & Federico Weinschelbaum, 2015. "The rise of noncommunicable diseases in Latin America and the Caribbean: challenges for public health policies," Latin American Economic Review, Springer;Centro de Investigaciòn y Docencia Económica (CIDE), vol. 24(1), pages 1-56, December.
    2. Loretta Giuliano & Calogero Edoardo Cicero & Elizabeth Blanca Crespo Gómez & Sandra Padilla & Elisa Bruno & Mario Camargo & Benoit Marin & Vito Sofia & Pierre-Marie Preux & Marianne Strohmeyer & Aless, 2017. "A screening questionnaire for convulsive seizures: A three-stage field-validation in rural Bolivia," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-11, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pntd00:0002480. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosntds (email available below). General contact details of provider: https://journals.plos.org/plosntds/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.