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Nifurtimox plus Eflornithine for Late-Stage Sleeping Sickness in Uganda: A Case Series

Author

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  • Francesco Checchi
  • Patrice Piola
  • Harriet Ayikoru
  • Florence Thomas
  • Dominique Legros
  • Gerardo Priotto

Abstract

Background: We report efficacy and safety outcomes from a prospective case series of 31 late-stage T.b. gambiense sleeping sickness (Human African Trypanosomiasis, HAT) patients treated with a combination of nifurtimox and eflornithine (N+E) in Yumbe, northwest Uganda in 2002–2003, following on a previously reported terminated trial in nearby Omugo, in which 17 patients received the combination under the same conditions. Methodology/Principal findings: Eligible sequential late-stage patients received 400 mg/Kg/day eflornithine (Ornidyl, Sanofi-Aventis) for seven days plus 15 mg/Kg/day (20 mg for children

Suggested Citation

  • Francesco Checchi & Patrice Piola & Harriet Ayikoru & Florence Thomas & Dominique Legros & Gerardo Priotto, 2007. "Nifurtimox plus Eflornithine for Late-Stage Sleeping Sickness in Uganda: A Case Series," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 1(2), pages 1-6, November.
    • Handle: RePEc:plo:pntd00:0000064
    DOI: 10.1371/journal.pntd.0000064
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