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Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study

Author

Listed:
  • Amit Kaura
  • Adam Hartley
  • Vasileios Panoulas
  • Ben Glampson
  • Anoop S V Shah
  • Jim Davies
  • Abdulrahim Mulla
  • Kerrie Woods
  • Joe Omigie
  • Anoop D Shah
  • Mark R Thursz
  • Paul Elliott
  • Harry Hemmingway
  • Bryan Williams
  • Folkert W Asselbergs
  • Michael O’Sullivan
  • Graham M Lord
  • Adam Trickey
  • Jonathan AC Sterne
  • Dorian O Haskard
  • Narbeh Melikian
  • Darrel P Francis
  • Wolfgang Koenig
  • Ajay M Shah
  • Rajesh Kharbanda
  • Divaka Perera
  • Riyaz S Patel
  • Keith M Channon
  • Jamil Mayet
  • Ramzi Khamis

Abstract

Background: There is limited evidence on the use of high-sensitivity C-reactive protein (hsCRP) as a biomarker for selecting patients for advanced cardiovascular (CV) therapies in the modern era. The prognostic value of mildly elevated hsCRP beyond troponin in a large real-world cohort of unselected patients presenting with suspected acute coronary syndrome (ACS) is unknown. We evaluated whether a mildly elevated hsCRP (up to 15 mg/L) was associated with mortality risk, beyond troponin level, in patients with suspected ACS. Methods and findings: We conducted a retrospective cohort study based on the National Institute for Health Research Health Informatics Collaborative data of 257,948 patients with suspected ACS who had a troponin measured at 5 cardiac centres in the United Kingdom between 2010 and 2017. Patients were divided into 4 hsCRP groups (

Suggested Citation

  • Amit Kaura & Adam Hartley & Vasileios Panoulas & Ben Glampson & Anoop S V Shah & Jim Davies & Abdulrahim Mulla & Kerrie Woods & Joe Omigie & Anoop D Shah & Mark R Thursz & Paul Elliott & Harry Hemming, 2022. "Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study," PLOS Medicine, Public Library of Science, vol. 19(2), pages 1-17, February.
    • Handle: RePEc:plo:pmed00:1003911
    DOI: 10.1371/journal.pmed.1003911
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