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Effectiveness and treatment moderators of internet interventions for adult problem drinking: An individual patient data meta-analysis of 19 randomised controlled trials

Author

Listed:
  • Heleen Riper
  • Adriaan Hoogendoorn
  • Pim Cuijpers
  • Eirini Karyotaki
  • Nikolaos Boumparis
  • Adriana Mira
  • Gerhard Andersson
  • Anne H Berman
  • Nicolas Bertholet
  • Gallus Bischof
  • Matthijs Blankers
  • Brigitte Boon
  • Leif Boß
  • Håvar Brendryen
  • John Cunningham
  • David Ebert
  • Anders Hansen
  • Reid Hester
  • Zarnie Khadjesari
  • Jeannet Kramer
  • Elizabeth Murray
  • Marloes Postel
  • Daniela Schulz
  • Kristina Sinadinovic
  • Brian Suffoletto
  • Christopher Sundström
  • Hein de Vries
  • Paul Wallace
  • Reinout W Wiers
  • Johannes H Smit

Abstract

Background: Face-to-face brief interventions for problem drinking are effective, but they have found limited implementation in routine care and the community. Internet-based interventions could overcome this treatment gap. We investigated effectiveness and moderators of treatment outcomes in internet-based interventions for adult problem drinking (iAIs). Methods and findings: Systematic searches were performed in medical and psychological databases to 31 December 2016. A one-stage individual patient data meta-analysis (IPDMA) was conducted with a linear mixed model complete-case approach, using baseline and first follow-up data. The primary outcome measure was mean weekly alcohol consumption in standard units (SUs, 10 grams of ethanol). Secondary outcome was treatment response (TR), defined as less than 14/21 SUs for women/men weekly. Putative participant, intervention, and study moderators were included. Robustness was verified in three sensitivity analyses: a two-stage IPDMA, a one-stage IPDMA using multiple imputation, and a missing-not-at-random (MNAR) analysis. We obtained baseline data for 14,198 adult participants (19 randomised controlled trials [RCTs], mean age 40.7 [SD = 13.2], 47.6% women). Their baseline mean weekly alcohol consumption was 38.1 SUs (SD = 26.9). Most were regular problem drinkers (80.1%, SUs 44.7, SD = 26.4) and 19.9% (SUs 11.9, SD = 4.1) were binge-only drinkers. About one third were heavy drinkers, meaning that women/men consumed, respectively, more than 35/50 SUs of alcohol at baseline (34.2%, SUs 65.9, SD = 27.1). Post-intervention data were available for 8,095 participants. Compared with controls, iAI participants showed a greater mean weekly decrease at follow-up of 5.02 SUs (95% CI −7.57 to −2.48, p

Suggested Citation

  • Heleen Riper & Adriaan Hoogendoorn & Pim Cuijpers & Eirini Karyotaki & Nikolaos Boumparis & Adriana Mira & Gerhard Andersson & Anne H Berman & Nicolas Bertholet & Gallus Bischof & Matthijs Blankers & , 2018. "Effectiveness and treatment moderators of internet interventions for adult problem drinking: An individual patient data meta-analysis of 19 randomised controlled trials," PLOS Medicine, Public Library of Science, vol. 15(12), pages 1-26, December.
  • Handle: RePEc:plo:pmed00:1002714
    DOI: 10.1371/journal.pmed.1002714
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    Cited by:

    1. Natale Salvatore Bonfiglio & Maria Lidia Mascia & Maria Pietronilla Penna, 2022. "Digital Treatment Paths for Substance Use Disorders (SUDs)," IJERPH, MDPI, vol. 19(12), pages 1-4, June.
    2. Gábor Kósa & Gergely Feher & Lilla Horvath & Ivan Zadori & Zsolt Nemeskeri & Miklos Kovacs & Éva Fejes & Janos Meszaros & Zoltan Banko & Antal Tibold, 2022. "Prevalence and Risk Factors of Problematic Internet Use among Hungarian Adult Recreational Esports Players," IJERPH, MDPI, vol. 19(6), pages 1-11, March.
    3. Jacques Simon Song & Hervé William Mougnol A Ekoula & Georges Ngnouwal Eloundou, 2024. "Alcohol consumption in developing countries: Does information and communication technology (ICT) diffusion matter?," Journal of International Development, John Wiley & Sons, Ltd., vol. 36(2), pages 1210-1240, March.
    4. Nystrand, Camilla & Gebreslassie, Mihretab & Ssegonja, Richard & Feldman, Inna & Sampaio, Filipa, 2021. "A systematic review of economic evaluations of public health interventions targeting alcohol, tobacco, illicit drug use and problematic gambling: Using a case study to assess transferability," Health Policy, Elsevier, vol. 125(1), pages 54-74.

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