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Assessing the neuroprotective benefits for babies of antenatal magnesium sulphate: An individual participant data meta-analysis

Author

Listed:
  • Caroline A Crowther
  • Philippa F Middleton
  • Merryn Voysey
  • Lisa Askie
  • Lelia Duley
  • Peter G Pryde
  • Stéphane Marret
  • Lex W Doyle
  • for the AMICABLE Group

Abstract

Background: Babies born preterm are at an increased risk of dying in the first weeks of life, and those who survive have a higher rate of cerebral palsy (CP) compared with babies born at term. The aim of this individual participant data (IPD) meta-analysis (MA) was to assess the effects of antenatal magnesium sulphate, compared with no magnesium treatment, given to women at risk of preterm birth on important maternal and fetal outcomes, including survival free of CP, and whether effects differed by participant or treatment characteristics such as the reason the woman was at risk of preterm birth, why treatment was given, the gestational age at which magnesium sulphate treatment was received, or the dose and timing of the administration of magnesium sulphate. Methods and findings: Trials in which women considered at risk of preterm birth (

Suggested Citation

  • Caroline A Crowther & Philippa F Middleton & Merryn Voysey & Lisa Askie & Lelia Duley & Peter G Pryde & Stéphane Marret & Lex W Doyle & for the AMICABLE Group, 2017. "Assessing the neuroprotective benefits for babies of antenatal magnesium sulphate: An individual participant data meta-analysis," PLOS Medicine, Public Library of Science, vol. 14(10), pages 1-24, October.
    • Handle: RePEc:plo:pmed00:1002398
    DOI: 10.1371/journal.pmed.1002398
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