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UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

Author

Listed:
  • Cathie Sudlow
  • John Gallacher
  • Naomi Allen
  • Valerie Beral
  • Paul Burton
  • John Danesh
  • Paul Downey
  • Paul Elliott
  • Jane Green
  • Martin Landray
  • Bette Liu
  • Paul Matthews
  • Giok Ong
  • Jill Pell
  • Alan Silman
  • Alan Young
  • Tim Sprosen
  • Tim Peakman
  • Rory Collins

Abstract

Cathie Sudlow and colleagues describe the UK Biobank, a large population-based prospective study, established to allow investigation of the genetic and non-genetic determinants of the diseases of middle and old age.

Suggested Citation

  • Cathie Sudlow & John Gallacher & Naomi Allen & Valerie Beral & Paul Burton & John Danesh & Paul Downey & Paul Elliott & Jane Green & Martin Landray & Bette Liu & Paul Matthews & Giok Ong & Jill Pell &, 2015. "UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age," PLOS Medicine, Public Library of Science, vol. 12(3), pages 1-10, March.
    • Handle: RePEc:plo:pmed00:1001779
    DOI: 10.1371/journal.pmed.1001779
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    References listed on IDEAS

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    1. Walter C. Willett & William J. Blot & Graham A. Colditz & Aaron R. Folsom & Brian E. Henderson & Meir J. Stampfer, 2007. "Merging and emerging cohorts: Not worth the wait," Nature, Nature, vol. 445(7125), pages 257-258, January.
    2. Francis S. Collins & Teri A. Manolio, 2007. "Merging and emerging cohorts: Necessary but not sufficient," Nature, Nature, vol. 445(7125), pages 259-259, January.
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    Cited by:

    1. Evelina T. Akimova & Tobias Wolfram & Xuejie Ding & Felix C. Tropf & Melinda C. Mills, 2025. "Polygenic prediction of occupational status GWAS elucidates genetic and environmental interplay in intergenerational transmission, careers and health in UK Biobank," Nature Human Behaviour, Nature, vol. 9(2), pages 391-405, February.
    2. Kevin M. Mendez & Stacey N. Reinke & Rachel S. Kelly & Qingwen Chen & Mark Su & Michael McGeachie & Scott Weiss & David I. Broadhurst & Jessica A. Lasky-Su, 2025. "A roadmap to precision medicine through post-genomic electronic medical records," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    3. Siru Yang & Mengmeng Li & Cui Guo & Weeberb J. Requia & Mohammad Javad Zare Sakhvidi & Kaili Lin & Qiongyu Zhu & Zhaoyue Chen & Peihua Cao & Lei Yang & Dan Luo & Jun Yang, 2025. "Associations of long-term exposure to nitrogen oxides with all-cause and cause-specific mortality," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    4. Jujiao Kang & Yue-Ting Deng & Bang-Sheng Wu & Wei-Shi Liu & Ze-Yu Li & Shitong Xiang & Liu Yang & Jia You & Xiaohong Gong & Tianye Jia & Jin-Tai Yu & Wei Cheng & Jianfeng Feng, 2024. "Whole exome sequencing analysis identifies genes for alcohol consumption," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Yi Fan & Chanchan Hu & Xiaoxu Xie & Yanfeng Weng & Chen Chen & Zhaokun Wang & Xueqiong He & Dongxia Jiang & Shaodan Huang & Zhijian Hu & Fengqiong Liu, 2024. "Effects of diets on risks of cancer and the mediating role of metabolites," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Liang-Dar Hwang & Justin D Tubbs & Justin Luong & Mischa Lundberg & Gunn-Helen Moen & Geng Wang & Nicole M Warrington & Pak C Sham & Gabriel Cuellar-Partida & David M Evans, 2020. "Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs," PLOS Genetics, Public Library of Science, vol. 16(10), pages 1-29, October.
    7. Sina Rüeger & Aaron McDaid & Zoltán Kutalik, 2018. "Evaluation and application of summary statistic imputation to discover new height-associated loci," PLOS Genetics, Public Library of Science, vol. 14(5), pages 1-32, May.
    8. Junyoung Park & Andrés Peña-Tauber & Lia Talozzi & Michael D. Greicius & Yann Guen, 2025. "Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    9. Samvida S. Venkatesh & Habib Ganjgahi & Duncan S. Palmer & Kayesha Coley & Gregorio V. Linchangco & Qin Hui & Peter Wilson & Yuk-Lam Ho & Kelly Cho & Kadri Arumäe & Laura B. L. Wittemans & Christoffer, 2024. "Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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