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Sleep-Disordered Breathing and Mortality: A Prospective Cohort Study

Author

Listed:
  • Naresh M Punjabi
  • Brian S Caffo
  • James L Goodwin
  • Daniel J Gottlieb
  • Anne B Newman
  • George T O'Connor
  • David M Rapoport
  • Susan Redline
  • Helaine E Resnick
  • John A Robbins
  • Eyal Shahar
  • Mark L Unruh
  • Jonathan M Samet

Abstract

In a cohort of 6,441 volunteers followed over an average of 8.2 years, Naresh Punjabi and colleagues find sleep-disordered breathing to be independently associated with mortality and identify predictive characteristics.Background: Sleep-disordered breathing is a common condition associated with adverse health outcomes including hypertension and cardiovascular disease. The overall objective of this study was to determine whether sleep-disordered breathing and its sequelae of intermittent hypoxemia and recurrent arousals are associated with mortality in a community sample of adults aged 40 years or older. Methods and Findings: We prospectively examined whether sleep-disordered breathing was associated with an increased risk of death from any cause in 6,441 men and women participating in the Sleep Heart Health Study. Sleep-disordered breathing was assessed with the apnea–hypopnea index (AHI) based on an in-home polysomnogram. Survival analysis and proportional hazards regression models were used to calculate hazard ratios for mortality after adjusting for age, sex, race, smoking status, body mass index, and prevalent medical conditions. The average follow-up period for the cohort was 8.2 y during which 1,047 participants (587 men and 460 women) died. Compared to those without sleep-disordered breathing (AHI:

Suggested Citation

  • Naresh M Punjabi & Brian S Caffo & James L Goodwin & Daniel J Gottlieb & Anne B Newman & George T O'Connor & David M Rapoport & Susan Redline & Helaine E Resnick & John A Robbins & Eyal Shahar & Mark , 2009. "Sleep-Disordered Breathing and Mortality: A Prospective Cohort Study," PLOS Medicine, Public Library of Science, vol. 6(8), pages 1-9, August.
    • Handle: RePEc:plo:pmed00:1000132
    DOI: 10.1371/journal.pmed.1000132
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    1. Bliwise, D.L. & Bliwise, N.G. & Partinen, M. & Pursley, A.M. & Dement, W.C., 1988. "Sleep apnea and mortality in an aged cohort," American Journal of Public Health, American Public Health Association, vol. 78(5), pages 544-547.
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