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Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study

Author

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  • Zitta B Harboe
  • Reimar W Thomsen
  • Anders Riis
  • Palle Valentiner-Branth
  • Jens Jørgen Christensen
  • Lotte Lambertsen
  • Karen A Krogfelt
  • Helle B Konradsen
  • Thomas L Benfield

Abstract

Analyzing population-based data collected over 30 years in more than 18,000 patients with invasive pneumococcal infection, Zitta Harboe and colleagues find specific pneumococcal serotypes to be associated with increased mortality.Background: Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). Methods and Findings: In a nationwide population-based cohort study of IPD in Denmark during 1977–2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio ≥3, p

Suggested Citation

  • Zitta B Harboe & Reimar W Thomsen & Anders Riis & Palle Valentiner-Branth & Jens Jørgen Christensen & Lotte Lambertsen & Karen A Krogfelt & Helle B Konradsen & Thomas L Benfield, 2009. "Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study," PLOS Medicine, Public Library of Science, vol. 6(5), pages 1-13, May.
    • Handle: RePEc:plo:pmed00:1000081
    DOI: 10.1371/journal.pmed.1000081
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