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Renal Function and Risk of Coronary Heart Disease in General Populations: New Prospective Study and Systematic Review

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  • Emanuele Di Angelantonio
  • John Danesh
  • Gudny Eiriksdottir
  • Vilmundur Gudnason

Abstract

Background: End-stage chronic kidney disease is associated with striking excesses of cardiovascular mortality, but it is uncertain to what extent renal function is related to risk of subsequent coronary heart disease (CHD) in apparently healthy adults. This study aims to quantify the association of markers of renal function with CHD risk in essentially general populations. Methods and Findings: Estimated glomerular filtration rate (eGFR) was calculated using standard prediction equations based on serum creatinine measurements made in 2,007 patients diagnosed with nonfatal myocardial infarction or coronary death during follow-up and in 3,869 people without CHD in the Reykjavik population-based cohort of 18,569 individuals. There were small and nonsignificant odds ratios (ORs) for CHD risk over most of the range in eGFR, except in the lowest category of the lowest fifth (corresponding to values of

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  • Emanuele Di Angelantonio & John Danesh & Gudny Eiriksdottir & Vilmundur Gudnason, 2007. "Renal Function and Risk of Coronary Heart Disease in General Populations: New Prospective Study and Systematic Review," PLOS Medicine, Public Library of Science, vol. 4(9), pages 1-11, September.
    • Handle: RePEc:plo:pmed00:0040270
    DOI: 10.1371/journal.pmed.0040270
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