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Travel-Related Venous Thrombosis: Results from a Large Population-Based Case Control Study (MEGA Study)

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  • Suzanne C Cannegieter
  • Carine J M Doggen
  • Hans C van Houwelingen
  • Frits R Rosendaal

Abstract

Background: Recent studies have indicated an increased risk of venous thrombosis after air travel. Nevertheless, questions on the magnitude of risk, the underlying mechanism, and modifying factors remain unanswered. Methods and Findings: We studied the effect of various modes and duration of travel on the risk of venous thrombosis in a large ongoing case-control study on risk factors for venous thrombosis in an unselected population (MEGA study). We also assessed the combined effect of travel and prothrombotic mutations, body mass index, height, and oral contraceptive use. Conclusions: The risk of venous thrombosis after travel is moderately increased for all modes of travel. Subgroups exist in which the risk is highly increased. In a large case-control study of travelers, the risk of venous thrombosis was increased 3-fold with a similar risk for flying or travelling by car, bus, or train. :

Suggested Citation

  • Suzanne C Cannegieter & Carine J M Doggen & Hans C van Houwelingen & Frits R Rosendaal, 2006. "Travel-Related Venous Thrombosis: Results from a Large Population-Based Case Control Study (MEGA Study)," PLOS Medicine, Public Library of Science, vol. 3(8), pages 1-8, August.
    • Handle: RePEc:plo:pmed00:0030307
    DOI: 10.1371/journal.pmed.0030307
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