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Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

Author

Listed:
  • Corina Lesseur
  • Aida Ferreiro-Iglesias
  • James D McKay
  • Yohan Bossé
  • Mattias Johansson
  • Valerie Gaborieau
  • Maria Teresa Landi
  • David C Christiani
  • Neil C Caporaso
  • Stig E Bojesen
  • Christopher I Amos
  • Sanjay Shete
  • Geoffrey Liu
  • Gadi Rennert
  • Demetrios Albanes
  • Melinda C Aldrich
  • Adonina Tardon
  • Chu Chen
  • Liloglou Triantafillos
  • John K Field
  • Marion Dawn Teare
  • Lambertus A Kiemeney
  • Brenda Diergaarde
  • Robert L Ferris
  • Shanbeh Zienolddiny
  • Stephen Lam
  • Andrew F Olshan
  • Mark C Weissler
  • Martin Lacko
  • Angela Risch
  • Heike Bickeböller
  • Andy R Ness
  • Steve Thomas
  • Loic Le Marchand
  • Matthew B Schabath
  • Victor Wünsch-Filho
  • Eloiza H Tajara
  • Angeline S Andrew
  • Gary M Clifford
  • Philip Lazarus
  • Kjell Grankvist
  • Mikael Johansson
  • Susanne Arnold
  • Olle Melander
  • Hans Brunnström
  • Stefania Boccia
  • Gabriella Cadoni
  • Wim Timens
  • Ma’en Obeidat
  • Xiangjun Xiao
  • Richard S Houlston
  • Rayjean J Hung
  • Paul Brennan

Abstract

Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta

Suggested Citation

  • Corina Lesseur & Aida Ferreiro-Iglesias & James D McKay & Yohan Bossé & Mattias Johansson & Valerie Gaborieau & Maria Teresa Landi & David C Christiani & Neil C Caporaso & Stig E Bojesen & Christopher, 2021. "Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers," PLOS Genetics, Public Library of Science, vol. 17(3), pages 1-19, March.
    • Handle: RePEc:plo:pgen00:1009254
    DOI: 10.1371/journal.pgen.1009254
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    Cited by:

    1. Go Sato & Yuya Shirai & Shinichi Namba & Ryuya Edahiro & Kyuto Sonehara & Tsuyoshi Hata & Mamoru Uemura & Koichi Matsuda & Yuichiro Doki & Hidetoshi Eguchi & Yukinori Okada, 2023. "Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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