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Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia

Author

Listed:
  • William K Scott
  • Felix Mba Medie
  • Felicia Ruffin
  • Batu K Sharma-Kuinkel
  • Derek D Cyr
  • Shengru Guo
  • Derek M Dykxhoorn
  • Robert L Skov
  • Niels E Bruun
  • Anders Dahl
  • Christian J Lerche
  • Andreas Petersen
  • Anders Rhod Larsen
  • Trine Kiilerich Lauridsen
  • Helle Krogh Johansen
  • Henrik Ullum
  • Erik Sørensen
  • Christian Hassager
  • Henning Bundgaard
  • Henrik C Schønheyder
  • Christian Torp-Pedersen
  • Louise Bruun Østergaard
  • Magnus Arpi
  • Flemming Rosenvinge
  • Lise T Erikstrup
  • Mahtab Chehri
  • Peter Søgaard
  • Paal S Andersen
  • Vance G Fowler Jr.

Abstract

The role of host genetic variation in the development of complicated Staphylococcus aureus bacteremia (SAB) is poorly understood. We used whole exome sequencing (WES) to examine the cumulative effect of coding variants in each gene on risk of complicated SAB in a discovery sample of 168 SAB cases (84 complicated and 84 uncomplicated, frequency matched by age, sex, and bacterial clonal complex [CC]), and then evaluated the most significantly associated genes in a replication sample of 240 SAB cases (122 complicated and 118 uncomplicated, frequency matched for age, sex, and CC) using targeted sequence capture. In the discovery sample, gene-based analysis using the SKAT-O program identified 334 genes associated with complicated SAB at p

Suggested Citation

  • William K Scott & Felix Mba Medie & Felicia Ruffin & Batu K Sharma-Kuinkel & Derek D Cyr & Shengru Guo & Derek M Dykxhoorn & Robert L Skov & Niels E Bruun & Anders Dahl & Christian J Lerche & Andreas , 2018. "Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia," PLOS Genetics, Public Library of Science, vol. 14(10), pages 1-22, October.
    • Handle: RePEc:plo:pgen00:1007667
    DOI: 10.1371/journal.pgen.1007667
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