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Selective and Genetic Constraints on Pneumococcal Serotype Switching

Author

Listed:
  • Nicholas J Croucher
  • Lisa Kagedan
  • Claudette M Thompson
  • Julian Parkhill
  • Stephen D Bentley
  • Jonathan A Finkelstein
  • Marc Lipsitch
  • William P Hanage

Abstract

Streptococcus pneumoniae isolates typically express one of over 90 immunologically distinguishable polysaccharide capsules (serotypes), which can be classified into “serogroups” based on cross-reactivity with certain antibodies. Pneumococci can alter their serotype through recombinations affecting the capsule polysaccharide synthesis (cps) locus. Twenty such “serotype switching” events were fully characterised using a collection of 616 whole genome sequences from systematic surveys of pneumococcal carriage. Eleven of these were within-serogroup switches, representing a highly significant (p

Suggested Citation

  • Nicholas J Croucher & Lisa Kagedan & Claudette M Thompson & Julian Parkhill & Stephen D Bentley & Jonathan A Finkelstein & Marc Lipsitch & William P Hanage, 2015. "Selective and Genetic Constraints on Pneumococcal Serotype Switching," PLOS Genetics, Public Library of Science, vol. 11(3), pages 1-21, March.
    • Handle: RePEc:plo:pgen00:1005095
    DOI: 10.1371/journal.pgen.1005095
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    References listed on IDEAS

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    1. Nicholas J. Croucher & Paul G. Coupland & Abbie E. Stevenson & Alanna Callendrello & Stephen D. Bentley & William P. Hanage, 2014. "Diversification of bacterial genome content through distinct mechanisms over different timescales," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    2. Rafal Mostowy & Nicholas J Croucher & William P Hanage & Simon R Harris & Stephen Bentley & Christophe Fraser, 2014. "Heterogeneity in the Frequency and Characteristics of Homologous Recombination in Pneumococcal Evolution," PLOS Genetics, Public Library of Science, vol. 10(5), pages 1-15, May.
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    Cited by:

    1. Uri Obolski & Todd D. Swarthout & Akuzike Kalizang’oma & Thandie S. Mwalukomo & Jia Mun Chan & Caroline M. Weight & Comfort Brown & Rory Cave & Jen Cornick & Arox Wadson Kamng’ona & Jacquline Msefula , 2023. "The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Matthieu Haudiquet & Julie Bris & Amandine Nucci & Rémy A. Bonnin & Pilar Domingo-Calap & Eduardo P. C. Rocha & Olaya Rendueles, 2024. "Capsules and their traits shape phage susceptibility and plasmid conjugation efficiency," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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