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Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

Author

Listed:
  • Anubha Mahajan
  • Xueling Sim
  • Hui Jin Ng
  • Alisa Manning
  • Manuel A Rivas
  • Heather M Highland
  • Adam E Locke
  • Niels Grarup
  • Hae Kyung Im
  • Pablo Cingolani
  • Jason Flannick
  • Pierre Fontanillas
  • Christian Fuchsberger
  • Kyle J Gaulton
  • Tanya M Teslovich
  • N William Rayner
  • Neil R Robertson
  • Nicola L Beer
  • Jana K Rundle
  • Jette Bork-Jensen
  • Claes Ladenvall
  • Christine Blancher
  • David Buck
  • Gemma Buck
  • Noël P Burtt
  • Stacey Gabriel
  • Anette P Gjesing
  • Christopher J Groves
  • Mette Hollensted
  • Jeroen R Huyghe
  • Anne U Jackson
  • Goo Jun
  • Johanne Marie Justesen
  • Massimo Mangino
  • Jacquelyn Murphy
  • Matt Neville
  • Robert Onofrio
  • Kerrin S Small
  • Heather M Stringham
  • Ann-Christine Syvänen
  • Joseph Trakalo
  • Goncalo Abecasis
  • Graeme I Bell
  • John Blangero
  • Nancy J Cox
  • Ravindranath Duggirala
  • Craig L Hanis
  • Mark Seielstad
  • James G Wilson
  • Cramer Christensen
  • Ivan Brandslund
  • Rainer Rauramaa
  • Gabriela L Surdulescu
  • Alex S F Doney
  • Lars Lannfelt
  • Allan Linneberg
  • Bo Isomaa
  • Tiinamaija Tuomi
  • Marit E Jørgensen
  • Torben Jørgensen
  • Johanna Kuusisto
  • Matti Uusitupa
  • Veikko Salomaa
  • Timothy D Spector
  • Andrew D Morris
  • Colin N A Palmer
  • Francis S Collins
  • Karen L Mohlke
  • Richard N Bergman
  • Erik Ingelsson
  • Lars Lind
  • Jaakko Tuomilehto
  • Torben Hansen
  • Richard M Watanabe
  • Inga Prokopenko
  • Josee Dupuis
  • Fredrik Karpe
  • Leif Groop
  • Markku Laakso
  • Oluf Pedersen
  • Jose C Florez
  • Andrew P Morris
  • David Altshuler
  • James B Meigs
  • Michael Boehnke
  • Mark I McCarthy
  • Cecilia M Lindgren
  • Anna L Gloyn
  • On Behalf of the T2D-GENES consortium and GoT2D consortium

Abstract

Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry. We found exome-wide significant (P

Suggested Citation

  • Anubha Mahajan & Xueling Sim & Hui Jin Ng & Alisa Manning & Manuel A Rivas & Heather M Highland & Adam E Locke & Niels Grarup & Hae Kyung Im & Pablo Cingolani & Jason Flannick & Pierre Fontanillas & C, 2015. "Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus," PLOS Genetics, Public Library of Science, vol. 11(1), pages 1-25, January.
    • Handle: RePEc:plo:pgen00:1004876
    DOI: 10.1371/journal.pgen.1004876
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