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Genome Wide Meta-analysis Highlights the Role of Genetic Variation in RARRES2 in the Regulation of Circulating Serum Chemerin

Author

Listed:
  • Anke Tönjes
  • Markus Scholz
  • Jana Breitfeld
  • Carola Marzi
  • Harald Grallert
  • Arnd Gross
  • Claes Ladenvall
  • Dorit Schleinitz
  • Kerstin Krause
  • Holger Kirsten
  • Esa Laurila
  • Jennifer Kriebel
  • Barbara Thorand
  • Wolfgang Rathmann
  • Leif Groop
  • Inga Prokopenko
  • Bo Isomaa
  • Frank Beutner
  • Jürgen Kratzsch
  • Joachim Thiery
  • Mathias Fasshauer
  • Nora Klöting
  • Christian Gieger
  • Matthias Blüher
  • Michael Stumvoll
  • Peter Kovacs

Abstract

Chemerin is an adipokine proposed to link obesity and chronic inflammation of adipose tissue. Genetic factors determining chemerin release from adipose tissue are yet unknown. We conducted a meta-analysis of genome-wide association studies (GWAS) for serum chemerin in three independent cohorts from Europe: Sorbs and KORA from Germany and PPP-Botnia from Finland (total N = 2,791). In addition, we measured mRNA expression of genes within the associated loci in peripheral mononuclear cells by micro-arrays, and within adipose tissue by quantitative RT-PCR and performed mRNA expression quantitative trait and expression-chemerin association studies to functionally substantiate our loci. Heritability estimate of circulating chemerin levels was 16.2% in the Sorbs cohort. Thirty single nucleotide polymorphisms (SNPs) at chromosome 7 within the retinoic acid receptor responder 2 (RARRES2)/Leucine Rich Repeat Containing (LRRC61) locus reached genome-wide significance (p

Suggested Citation

  • Anke Tönjes & Markus Scholz & Jana Breitfeld & Carola Marzi & Harald Grallert & Arnd Gross & Claes Ladenvall & Dorit Schleinitz & Kerstin Krause & Holger Kirsten & Esa Laurila & Jennifer Kriebel & Bar, 2014. "Genome Wide Meta-analysis Highlights the Role of Genetic Variation in RARRES2 in the Regulation of Circulating Serum Chemerin," PLOS Genetics, Public Library of Science, vol. 10(12), pages 1-11, December.
    • Handle: RePEc:plo:pgen00:1004854
    DOI: 10.1371/journal.pgen.1004854
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