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Large-scale Metabolomic Profiling Identifies Novel Biomarkers for Incident Coronary Heart Disease

Author

Listed:
  • Andrea Ganna
  • Samira Salihovic
  • Johan Sundström
  • Corey D Broeckling
  • Åsa K Hedman
  • Patrik K E Magnusson
  • Nancy L Pedersen
  • Anders Larsson
  • Agneta Siegbahn
  • Mihkel Zilmer
  • Jessica Prenni
  • Johan Ärnlöv
  • Lars Lind
  • Tove Fall
  • Erik Ingelsson

Abstract

Analyses of circulating metabolites in large prospective epidemiological studies could lead to improved prediction and better biological understanding of coronary heart disease (CHD). We performed a mass spectrometry-based non-targeted metabolomics study for association with incident CHD events in 1,028 individuals (131 events; 10 y. median follow-up) with validation in 1,670 individuals (282 events; 3.9 y. median follow-up). Four metabolites were replicated and independent of main cardiovascular risk factors [lysophosphatidylcholine 18∶1 (hazard ratio [HR] per standard deviation [SD] increment = 0.77, P-value

Suggested Citation

  • Andrea Ganna & Samira Salihovic & Johan Sundström & Corey D Broeckling & Åsa K Hedman & Patrik K E Magnusson & Nancy L Pedersen & Anders Larsson & Agneta Siegbahn & Mihkel Zilmer & Jessica Prenni & Jo, 2014. "Large-scale Metabolomic Profiling Identifies Novel Biomarkers for Incident Coronary Heart Disease," PLOS Genetics, Public Library of Science, vol. 10(12), pages 1-10, December.
    • Handle: RePEc:plo:pgen00:1004801
    DOI: 10.1371/journal.pgen.1004801
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    1. Rozenn N Lemaitre & Toshiko Tanaka & Weihong Tang & Ani Manichaikul & Millennia Foy & Edmond K Kabagambe & Jennifer A Nettleton & Irena B King & Lu-Chen Weng & Sayanti Bhattacharya & Stefania Bandinel, 2011. "Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium," PLOS Genetics, Public Library of Science, vol. 7(7), pages 1-12, July.
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