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Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

Author

Listed:
  • Jennifer L Bolton
  • Caroline Hayward
  • Nese Direk
  • John G Lewis
  • Geoffrey L Hammond
  • Lesley A Hill
  • Anna Anderson
  • Jennifer Huffman
  • James F Wilson
  • Harry Campbell
  • Igor Rudan
  • Alan Wright
  • Nicholas Hastie
  • Sarah H Wild
  • Fleur P Velders
  • Albert Hofman
  • Andre G Uitterlinden
  • Jari Lahti
  • Katri Räikkönen
  • Eero Kajantie
  • Elisabeth Widen
  • Aarno Palotie
  • Johan G Eriksson
  • Marika Kaakinen
  • Marjo-Riitta Järvelin
  • Nicholas J Timpson
  • George Davey Smith
  • Susan M Ring
  • David M Evans
  • Beate St Pourcain
  • Toshiko Tanaka
  • Yuri Milaneschi
  • Stefania Bandinelli
  • Luigi Ferrucci
  • Pim van der Harst
  • Judith G M Rosmalen
  • Stephen J L Bakker
  • Niek Verweij
  • Robin P F Dullaart
  • Anubha Mahajan
  • Cecilia M Lindgren
  • Andrew Morris
  • Lars Lind
  • Erik Ingelsson
  • Laura N Anderson
  • Craig E Pennell
  • Stephen J Lye
  • Stephen G Matthews
  • Joel Eriksson
  • Dan Mellstrom
  • Claes Ohlsson
  • Jackie F Price
  • Mark W J Strachan
  • Rebecca M Reynolds
  • Henning Tiemeier
  • Brian R Walker
  • on behalf of the CORtisol NETwork (CORNET) Consortium

Abstract

Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30–60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that

Suggested Citation

  • Jennifer L Bolton & Caroline Hayward & Nese Direk & John G Lewis & Geoffrey L Hammond & Lesley A Hill & Anna Anderson & Jennifer Huffman & James F Wilson & Harry Campbell & Igor Rudan & Alan Wright & , 2014. "Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin," PLOS Genetics, Public Library of Science, vol. 10(7), pages 1-11, July.
    • Handle: RePEc:plo:pgen00:1004474
    DOI: 10.1371/journal.pgen.1004474
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