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Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

Author

Listed:
  • Gordan Lauc
  • Jennifer E Huffman
  • Maja Pučić
  • Lina Zgaga
  • Barbara Adamczyk
  • Ana Mužinić
  • Mislav Novokmet
  • Ozren Polašek
  • Olga Gornik
  • Jasminka Krištić
  • Toma Keser
  • Veronique Vitart
  • Blanca Scheijen
  • Hae-Won Uh
  • Mariam Molokhia
  • Alan Leslie Patrick
  • Paul McKeigue
  • Ivana Kolčić
  • Ivan Krešimir Lukić
  • Olivia Swann
  • Frank N van Leeuwen
  • L Renee Ruhaak
  • Jeanine J Houwing-Duistermaat
  • P Eline Slagboom
  • Marian Beekman
  • Anton J M de Craen
  • André M Deelder
  • Qiang Zeng
  • Wei Wang
  • Nicholas D Hastie
  • Ulf Gyllensten
  • James F Wilson
  • Manfred Wuhrer
  • Alan F Wright
  • Pauline M Rudd
  • Caroline Hayward
  • Yurii Aulchenko
  • Harry Campbell
  • Igor Rudan

Abstract

Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. After isolating IgG from human plasma, we performed 77 quantitative measurements of N-glycosylation using ultra-performance liquid chromatography (UPLC) in 2,247 individuals from four European discovery populations. In parallel, we measured IgG N-glycans using MALDI-TOF mass spectrometry (MS) in a replication cohort of 1,848 Europeans. Meta-analysis of genome-wide association study (GWAS) results identified 9 genome-wide significant loci (P

Suggested Citation

  • Gordan Lauc & Jennifer E Huffman & Maja Pučić & Lina Zgaga & Barbara Adamczyk & Ana Mužinić & Mislav Novokmet & Ozren Polašek & Olga Gornik & Jasminka Krištić & Toma Keser & Veronique Vitart & Blanca , 2013. "Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers," PLOS Genetics, Public Library of Science, vol. 9(1), pages 1-17, January.
    • Handle: RePEc:plo:pgen00:1003225
    DOI: 10.1371/journal.pgen.1003225
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    Cited by:

    1. Lili Liu & Atlas Khan & Elena Sanchez-Rodriguez & Francesca Zanoni & Yifu Li & Nicholas Steers & Olivia Balderes & Junying Zhang & Priya Krithivasan & Robert A. LeDesma & Clara Fischman & Scott J. Heb, 2022. "Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. el Bouhaddani, Said & Uh, Hae-Won & Hayward, Caroline & Jongbloed, Geurt & Houwing-Duistermaat, Jeanine, 2018. "Probabilistic partial least squares model: Identifiability, estimation and application," Journal of Multivariate Analysis, Elsevier, vol. 167(C), pages 331-346.
    3. Arianna Landini & Irena Trbojević-Akmačić & Pau Navarro & Yakov A. Tsepilov & Sodbo Z. Sharapov & Frano Vučković & Ozren Polašek & Caroline Hayward & Tea Petrović & Marija Vilaj & Yurii S. Aulchenko &, 2022. "Genetic regulation of post-translational modification of two distinct proteins," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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