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Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals

Author

Listed:
  • Yingleong Chan
  • Oddgeir L Holmen
  • Andrew Dauber
  • Lars Vatten
  • Aki S Havulinna
  • Frank Skorpen
  • Kirsti Kvaløy
  • Kaisa Silander
  • Thutrang T Nguyen
  • Cristen Willer
  • Michael Boehnke
  • Markus Perola
  • Aarno Palotie
  • Veikko Salomaa
  • Kristian Hveem
  • Timothy M Frayling
  • Joel N Hirschhorn
  • Michael N Weedon

Abstract

Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation determines the phenotype of highly heritable traits such as height is uncertain, as is the extent to which common variation is relevant to individuals with more extreme phenotypes. To address these questions, we studied 1,214 individuals from the top and bottom extremes of the height distribution (tallest and shortest ∼1.5%), drawn from ∼78,000 individuals from the HUNT and FINRISK cohorts. We found that common variants still influence height at the extremes of the distribution: common variants (49/141) were nominally associated with height in the expected direction more often than is expected by chance (p

Suggested Citation

  • Yingleong Chan & Oddgeir L Holmen & Andrew Dauber & Lars Vatten & Aki S Havulinna & Frank Skorpen & Kirsti Kvaløy & Kaisa Silander & Thutrang T Nguyen & Cristen Willer & Michael Boehnke & Markus Perol, 2011. "Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals," PLOS Genetics, Public Library of Science, vol. 7(12), pages 1-11, December.
    • Handle: RePEc:plo:pgen00:1002439
    DOI: 10.1371/journal.pgen.1002439
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