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Genetic Determinants of Serum Testosterone Concentrations in Men

Author

Listed:
  • Claes Ohlsson
  • Henri Wallaschofski
  • Kathryn L Lunetta
  • Lisette Stolk
  • John R B Perry
  • Annemarie Koster
  • Ann-Kristin Petersen
  • Joel Eriksson
  • Terho Lehtimäki
  • Ilpo T Huhtaniemi
  • Geoffrey L Hammond
  • Marcello Maggio
  • Andrea D Coviello
  • EMAS Study Group
  • Luigi Ferrucci
  • Margit Heier
  • Albert Hofman
  • Kate L Holliday
  • John-Olov Jansson
  • Mika Kähönen
  • David Karasik
  • Magnus K Karlsson
  • Douglas P Kiel
  • Yongmei Liu
  • Östen Ljunggren
  • Mattias Lorentzon
  • Leo-Pekka Lyytikäinen
  • Thomas Meitinger
  • Dan Mellström
  • David Melzer
  • Iva Miljkovic
  • Matthias Nauck
  • Maria Nilsson
  • Brenda Penninx
  • Stephen R Pye
  • Ramachandran S Vasan
  • Martin Reincke
  • Fernando Rivadeneira
  • Abdelouahid Tajar
  • Alexander Teumer
  • André G Uitterlinden
  • Jagadish Ulloor
  • Jorma Viikari
  • Uwe Völker
  • Henry Völzke
  • H Erich Wichmann
  • Tsung-Sheng Wu
  • Wei Vivian Zhuang
  • Elad Ziv
  • Frederick C W Wu
  • Olli Raitakari
  • Anna Eriksson
  • Martin Bidlingmaier
  • Tamara B Harris
  • Anna Murray
  • Frank H de Jong
  • Joanne M Murabito
  • Shalender Bhasin
  • Liesbeth Vandenput
  • Robin Haring

Abstract

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as

Suggested Citation

  • Claes Ohlsson & Henri Wallaschofski & Kathryn L Lunetta & Lisette Stolk & John R B Perry & Annemarie Koster & Ann-Kristin Petersen & Joel Eriksson & Terho Lehtimäki & Ilpo T Huhtaniemi & Geoffrey L Ha, 2011. "Genetic Determinants of Serum Testosterone Concentrations in Men," PLOS Genetics, Public Library of Science, vol. 7(10), pages 1-11, October.
    • Handle: RePEc:plo:pgen00:1002313
    DOI: 10.1371/journal.pgen.1002313
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    Cited by:

    1. Eibich, Peter & Kanabar, Ricky & Plum, Alexander & Schmied, Julian, 2022. "In and out of unemployment—Labour market transitions and the role of testosterone," Economics & Human Biology, Elsevier, vol. 46(C).
    2. Jennifer Prescott & Deborah J Thompson & Peter Kraft & Stephen J Chanock & Tina Audley & Judith Brown & Jean Leyland & Elizabeth Folkerd & Deborah Doody & Susan E Hankinson & David J Hunter & Kevin B , 2012. "Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-8, June.

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