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Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD

Author

Listed:
  • Carsten A Böger
  • Mathias Gorski
  • Man Li
  • Michael M Hoffmann
  • Chunmei Huang
  • Qiong Yang
  • Alexander Teumer
  • Vera Krane
  • Conall M O'Seaghdha
  • Zoltán Kutalik
  • H-Erich Wichmann
  • Thomas Haak
  • Eva Boes
  • Stefan Coassin
  • Josef Coresh
  • Barbara Kollerits
  • Margot Haun
  • Bernhard Paulweber
  • Anna Köttgen
  • Guo Li
  • Michael G Shlipak
  • Neil Powe
  • Shih-Jen Hwang
  • Abbas Dehghan
  • Fernando Rivadeneira
  • André Uitterlinden
  • Albert Hofman
  • Jacques S Beckmann
  • Bernhard K Krämer
  • Jacqueline Witteman
  • Murielle Bochud
  • David Siscovick
  • Rainer Rettig
  • Florian Kronenberg
  • Christoph Wanner
  • Ravi I Thadhani
  • Iris M Heid
  • Caroline S Fox
  • W H Kao
  • The CKDGen Consortium

Abstract

Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident CKD cases defined as eGFR

Suggested Citation

  • Carsten A Böger & Mathias Gorski & Man Li & Michael M Hoffmann & Chunmei Huang & Qiong Yang & Alexander Teumer & Vera Krane & Conall M O'Seaghdha & Zoltán Kutalik & H-Erich Wichmann & Thomas Haak & Ev, 2011. "Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD," PLOS Genetics, Public Library of Science, vol. 7(9), pages 1-8, September.
    • Handle: RePEc:plo:pgen00:1002292
    DOI: 10.1371/journal.pgen.1002292
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