IDEAS home Printed from https://ideas.repec.org/a/plo/pgen00/1001283.html
   My bibliography  Save this article

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

Author

Listed:
  • Eleonora A M Festen
  • Philippe Goyette
  • Todd Green
  • Gabrielle Boucher
  • Claudine Beauchamp
  • Gosia Trynka
  • Patrick C Dubois
  • Caroline Lagacé
  • Pieter C F Stokkers
  • Daan W Hommes
  • Donatella Barisani
  • Orazio Palmieri
  • Vito Annese
  • David A van Heel
  • Rinse K Weersma
  • Mark J Daly
  • Cisca Wijmenga
  • John D Rioux

Abstract

Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies suggest that CelD patients have a higher risk to develop CD than the general population. These observations suggest that CD and CelD may share common genetic risk loci. Two such shared loci, IL18RAP and PTPN2, have already been identified independently in these two diseases. The aim of our study was to explicitly identify shared risk loci for these diseases by combining results from genome-wide association study (GWAS) datasets of CD and CelD. Specifically, GWAS results from CelD (768 cases, 1,422 controls) and CD (3,230 cases, 4,829 controls) were combined in a meta-analysis. Nine independent regions had nominal association p-value

Suggested Citation

  • Eleonora A M Festen & Philippe Goyette & Todd Green & Gabrielle Boucher & Claudine Beauchamp & Gosia Trynka & Patrick C Dubois & Caroline Lagacé & Pieter C F Stokkers & Daan W Hommes & Donatella Baris, 2011. "A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease," PLOS Genetics, Public Library of Science, vol. 7(1), pages 1-6, January.
    • Handle: RePEc:plo:pgen00:1001283
    DOI: 10.1371/journal.pgen.1001283
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1001283
    Download Restriction: no
    File URL: https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001283&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pgen.1001283?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Diana Chang & Alon Keinan, 2014. "Principal Component Analysis Characterizes Shared Pathogenetics from Genome-Wide Association Studies," PLOS Computational Biology, Public Library of Science, vol. 10(9), pages 1-14, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pgen00:1001283. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosgenetics (email available below). General contact details of provider: https://journals.plos.org/plosgenetics/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.