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Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo

Author

Listed:
  • M Kamran Ikram
  • Sim Xueling
  • Richard A Jensen
  • Mary Frances Cotch
  • Alex W Hewitt
  • M Arfan Ikram
  • Jie Jin Wang
  • Ronald Klein
  • Barbara E K Klein
  • Monique M B Breteler
  • Ning Cheung
  • Gerald Liew
  • Paul Mitchell
  • Andre G Uitterlinden
  • Fernando Rivadeneira
  • Albert Hofman
  • Paulus T V M de Jong
  • Cornelia M van Duijn
  • Linda Kao
  • Ching-Yu Cheng
  • Albert Vernon Smith
  • Nicole L Glazer
  • Thomas Lumley
  • Barbara McKnight
  • Bruce M Psaty
  • Fridbert Jonasson
  • Gudny Eiriksdottir
  • Thor Aspelund
  • Global BPgen Consortium
  • Tamara B Harris
  • Lenore J Launer
  • Kent D Taylor
  • Xiaohui Li
  • Sudha K Iyengar
  • Quansheng Xi
  • Theru A Sivakumaran
  • David A Mackey
  • Stuart MacGregor
  • Nicholas G Martin
  • Terri L Young
  • Josh C Bis
  • Kerri L Wiggins
  • Susan R Heckbert
  • Christopher J Hammond
  • Toby Andrew
  • Samantha Fahy
  • John Attia
  • Elizabeth G Holliday
  • Rodney J Scott
  • F M Amirul Islam
  • Jerome I Rotter
  • Annie K McAuley
  • Eric Boerwinkle
  • E Shyong Tai
  • Vilmundur Gudnason
  • David S Siscovick
  • Johannes R Vingerling
  • Tien Y Wong

Abstract

There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n = 6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP) spread across five loci were significantly associated (p

Suggested Citation

  • M Kamran Ikram & Sim Xueling & Richard A Jensen & Mary Frances Cotch & Alex W Hewitt & M Arfan Ikram & Jie Jin Wang & Ronald Klein & Barbara E K Klein & Monique M B Breteler & Ning Cheung & Gerald Lie, 2010. "Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo," PLOS Genetics, Public Library of Science, vol. 6(10), pages 1-12, October.
    • Handle: RePEc:plo:pgen00:1001184
    DOI: 10.1371/journal.pgen.1001184
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    Cited by:

    1. Young Lee & Suyeon Park & Sanghoon Moon & Juyoung Lee & Robert C. Elston & Woojoo Lee & Sungho Won, 2014. "On the Analysis of a Repeated Measure Design in Genome-Wide Association Analysis," IJERPH, MDPI, vol. 11(12), pages 1-21, November.

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