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Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

Author

Listed:
  • Demetris Pillas
  • Clive J Hoggart
  • David M Evans
  • Paul F O'Reilly
  • Kirsi Sipilä
  • Raija Lähdesmäki
  • Iona Y Millwood
  • Marika Kaakinen
  • Gopalakrishnan Netuveli
  • David Blane
  • Pimphen Charoen
  • Ulla Sovio
  • Anneli Pouta
  • Nelson Freimer
  • Anna-Liisa Hartikainen
  • Jaana Laitinen
  • Sarianna Vaara
  • Beate Glaser
  • Peter Crawford
  • Nicholas J Timpson
  • Susan M Ring
  • Guohong Deng
  • Weihua Zhang
  • Mark I McCarthy
  • Panos Deloukas
  • Leena Peltonen
  • Paul Elliott
  • Lachlan J M Coin
  • George Davey Smith
  • Marjo-Riitta Jarvelin

Abstract

Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P

Suggested Citation

  • Demetris Pillas & Clive J Hoggart & David M Evans & Paul F O'Reilly & Kirsi Sipilä & Raija Lähdesmäki & Iona Y Millwood & Marika Kaakinen & Gopalakrishnan Netuveli & David Blane & Pimphen Charoen & Ul, 2010. "Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy," PLOS Genetics, Public Library of Science, vol. 6(2), pages 1-7, February.
    • Handle: RePEc:plo:pgen00:1000856
    DOI: 10.1371/journal.pgen.1000856
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