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A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose

Author

Listed:
  • Fumihiko Takeuchi
  • Ralph McGinnis
  • Stephane Bourgeois
  • Chris Barnes
  • Niclas Eriksson
  • Nicole Soranzo
  • Pamela Whittaker
  • Venkatesh Ranganath
  • Vasudev Kumanduri
  • William McLaren
  • Lennart Holm
  • Jonatan Lindh
  • Anders Rane
  • Mia Wadelius
  • Panos Deloukas

Abstract

We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to detect genome-wide significance (p

Suggested Citation

  • Fumihiko Takeuchi & Ralph McGinnis & Stephane Bourgeois & Chris Barnes & Niclas Eriksson & Nicole Soranzo & Pamela Whittaker & Venkatesh Ranganath & Vasudev Kumanduri & William McLaren & Lennart Holm , 2009. "A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose," PLOS Genetics, Public Library of Science, vol. 5(3), pages 1-9, March.
    • Handle: RePEc:plo:pgen00:1000433
    DOI: 10.1371/journal.pgen.1000433
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    Cited by:

    1. Andrea L Jorgensen & Richard J FitzGerald & James Oyee & Munir Pirmohamed & Paula R Williamson, 2012. "Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-1, August.

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