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Three Drug Combinations for Late-Stage Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda

Author

Listed:
  • Gerardo Priotto
  • Carole Fogg
  • Manica Balasegaram
  • Olema Erphas
  • Albino Louga
  • Francesco Checchi
  • Salah Ghabri
  • Patrice Piola

Abstract

Objectives: Our objective was to compare the efficacy and safety of three drug combinations for the treatment of late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense. Design: This trial was a randomized, open-label, active control, parallel clinical trial comparing three arms. Setting: The study took place at the Sleeping Sickness Treatment Center run by Médecins Sans Frontières at Omugo, Arua District, Uganda Participants: Stage 2 patients diagnosed in Northern Uganda were screened for inclusion and a total of 54 selected. Interventions: Three drug combinations were given to randomly assigned patients: melarsoprol-nifurtimox (M+N), melarsoprol-eflornithine (M+E), and nifurtimox-eflornithine (N+E). Dosages were uniform: intravenous (IV) melarsoprol 1.8 mg/kg/d, daily for 10 d; IV eflornithine 400 mg/kg/d, every 6 h for 7 d; oral nifurtimox 15 (adults) or 20 (children

Suggested Citation

  • Gerardo Priotto & Carole Fogg & Manica Balasegaram & Olema Erphas & Albino Louga & Francesco Checchi & Salah Ghabri & Patrice Piola, 2006. "Three Drug Combinations for Late-Stage Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda," PLOS Clinical Trials, Public Library of Science, vol. 1(8), pages 1-8, December.
    • Handle: RePEc:plo:pctr00:0010039
    DOI: 10.1371/journal.pctr.0010039
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