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Ten steps to investigate a cellular system with mathematical modeling

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  • Jasia King
  • Kerbaï Saïd Eroumé
  • Roman Truckenmüller
  • Stefan Giselbrecht
  • Ann E Cowan
  • Leslie Loew
  • Aurélie Carlier

Abstract

Cellular and intracellular processes are inherently complex due to the large number of components and interactions, which are often nonlinear and occur at different spatiotemporal scales. Because of this complexity, mathematical modeling is increasingly used to simulate such systems and perform experiments in silico, many orders of magnitude faster than real experiments and often at a higher spatiotemporal resolution. In this article, we will focus on the generic modeling process and illustrate it with an example model of membrane lipid turnover.

Suggested Citation

  • Jasia King & Kerbaï Saïd Eroumé & Roman Truckenmüller & Stefan Giselbrecht & Ann E Cowan & Leslie Loew & Aurélie Carlier, 2021. "Ten steps to investigate a cellular system with mathematical modeling," PLOS Computational Biology, Public Library of Science, vol. 17(5), pages 1-8, May.
    • Handle: RePEc:plo:pcbi00:1008921
    DOI: 10.1371/journal.pcbi.1008921
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    References listed on IDEAS

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    1. Francis Mairet & Olivier Bernard, 2019. "Twelve quick tips for designing sound dynamical models for bioprocesses," PLOS Computational Biology, Public Library of Science, vol. 15(8), pages 1-8, August.
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