IDEAS home Printed from https://ideas.repec.org/a/plo/pcbi00/1004951.html
   My bibliography  Save this article

Modelling Virus and Antibody Dynamics during Dengue Virus Infection Suggests a Role for Antibody in Virus Clearance

Author

Listed:
  • Hannah E Clapham
  • Than Ha Quyen
  • Duong Thi Hue Kien
  • Ilaria Dorigatti
  • Cameron P Simmons
  • Neil M Ferguson

Abstract

Dengue is an infection of increasing global importance, yet uncertainty remains regarding critical aspects of its virology, immunology and epidemiology. One unanswered question is how infection is controlled and cleared during a dengue infection. Antibody is thought to play a role, but little past work has examined the kinetics of both virus and antibody during natural infections. We present data on multiple virus and antibody titres measurements recorded sequentially during infection from 53 Vietnamese dengue patients. We fit mechanistic mathematical models of the dynamics of viral replication and the host immune response to these data. These models fit the data well. The model with antibody removing virus fits the data best, but with a role suggested for ADCC or other infected cell clearance mechanisms. Our analysis therefore shows that the observed viral and antibody kinetics are consistent with antibody playing a key role in controlling viral replication. This work gives quantitative insight into the relationship between antibody levels and the efficiency of viral clearance. It will inform the future development of mechanistic models of how vaccines and antivirals might modify the course of natural dengue infection.Author Summary: Dengue is a globally important viral disease. Despite this, there is still much unknown about the immunology, virology and epidemiology of dengue. As for all viral infections, the interaction between virus and immune response is a complex one. Using data collected from patients, we model how the virus replicates in an infected individual and how the human antibody response acts to control that replication. We show that the timing and magnitude of the growth and decline of virus and antibody levels in dengue-infected patients are consistent with antibody playing a key role in controlling infection. Our results are of use in the evaluation of potential antiviral drugs and vaccines.

Suggested Citation

  • Hannah E Clapham & Than Ha Quyen & Duong Thi Hue Kien & Ilaria Dorigatti & Cameron P Simmons & Neil M Ferguson, 2016. "Modelling Virus and Antibody Dynamics during Dengue Virus Infection Suggests a Role for Antibody in Virus Clearance," PLOS Computational Biology, Public Library of Science, vol. 12(5), pages 1-15, May.
    • Handle: RePEc:plo:pcbi00:1004951
    DOI: 10.1371/journal.pcbi.1004951
    as

    Download full text from publisher

    File URL: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004951
    Download Restriction: no
    File URL: https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004951&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pcbi.1004951?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Rotem Ben-Shachar & Scott Schmidler & Katia Koelle, 2016. "Drivers of Inter-individual Variation in Dengue Viral Load Dynamics," PLOS Computational Biology, Public Library of Science, vol. 12(11), pages 1-26, November.
    2. G. Sanglier Contreras & M. Robas Mora & P. Jimenez Gómez, 2020. "Analysis of Data on Socio-Demographic and Clinical Factors of the COVID-19 Coronavirus Epidemic in Spain on Cases of Recovered and Death Cases," Modern Applied Science, Canadian Center of Science and Education, vol. 14(8), pages 1-9, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pcbi00:1004951. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: ploscompbiol (email available below). General contact details of provider: https://journals.plos.org/ploscompbiol/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.