Modelling Odor Decoding in the Antennal Lobe by Combining Sequential Firing Rate Models with Bayesian Inference

The olfactory information that is received by the insect brain is encoded in the form of spatiotemporal patterns in the projection neurons of the antennal lobe. These dense and overlapping patterns are transformed into a sparse code in Kenyon cells in the mushroom body. Although it is clear that this sparse code is the basis for rapid categorization of odors, it is yet unclear how the sparse code in Kenyon cells is computed and what information it represents. Here we show that this computation can be modeled by sequential firing rate patterns using Lotka-Volterra equations and Bayesian online inference. This new model can be understood as an ‘intelligent coincidence detector’, which robustly and dynamically encodes the presence of specific odor features. We found that the model is able to qualitatively reproduce experimentally observed activity in both the projection neurons and the Kenyon cells. In particular, the model explains mechanistically how sparse activity in the Kenyon cells arises from the dense code in the projection neurons. The odor classification performance of the model proved to be robust against noise and time jitter in the observed input sequences. As in recent experimental results, we found that recognition of an odor happened very early during stimulus presentation in the model. Critically, by using the model, we found surprising but simple computational explanations for several experimental phenomena.Author Summary: Odor recognition in the insect brain is amazingly fast but still not fully understood. It is known that recognition is performed in three stages. In the first stage, the sensors respond to an odor by displaying a reproducible neuronal pattern. This code is turned, in the second and third stages, into a sparse code, that is, only relatively few neurons activate over hundreds of milliseconds. It is generally assumed that the insect brain uses this temporal code to recognize an odor. We propose a new model of how this temporal code emerges using sequential activation of groups of neurons. We show that these sequential activations underlie a fast and accurate recognition which is highly robust against neuronal or sensory noise. This model replicates several key experimental findings and explains how the insect brain achieves both speed and robustness of odor recognition as observed in experiments.