miRTex: A Text Mining System for miRNA-Gene Relation Extraction

MicroRNAs (miRNAs) regulate a wide range of cellular and developmental processes through gene expression suppression or mRNA degradation. Experimentally validated miRNA gene targets are often reported in the literature. In this paper, we describe miRTex, a text mining system that extracts miRNA-target relations, as well as miRNA-gene and gene-miRNA regulation relations. The system achieves good precision and recall when evaluated on a literature corpus of 150 abstracts with F-scores close to 0.90 on the three different types of relations. We conducted full-scale text mining using miRTex to process all the Medline abstracts and all the full-length articles in the PubMed Central Open Access Subset. The results for all the Medline abstracts are stored in a database for interactive query and file download via the website at http://proteininformationresource.org/mirtex. Using miRTex, we identified genes potentially regulated by miRNAs in Triple Negative Breast Cancer, as well as miRNA-gene relations that, in conjunction with kinase-substrate relations, regulate the response to abiotic stress in Arabidopsis thaliana. These two use cases demonstrate the usefulness of miRTex text mining in the analysis of miRNA-regulated biological processes.Author Summary: MicroRNAs (miRNAs) are an important class of RNAs that regulate a wide range of biological processes by post-transcriptional regulation of gene expression. The amount of literature describing experimentally validated miRNA targets is increasing rapidly, which poses a challenge to researchers and biocurators to stay up-to-date with the available information. Text mining methods have been used to extract miRNA-gene associated pairs and assist in curation. In this paper, we describe miRTex, a text mining system that extracts miRNA-target, miRNA-gene regulation and gene-miRNA regulation relations. We evaluate miRTex performance on two corpora, and show that the elaborate use of lexico-syntactic information and linguistic generalizations enables it to achieve the state-of-the-art performance. We have processed the all the Medline abstracts and all the full-length articles in the PubMed Central Open Access Subset with miRTex, and provide a website to access the extraction results from all the Medline abstracts. The full-scale text mining results will be a useful resource for miRNA researchers, while the miRTex tool itself can be integrated into literature-based curation pipelines. We present two use cases (for animal and plant miRNAs, respectively) that show how the full-scale text mining can be used in combination with other bioinformatics resources to gain insight into biological processes.