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Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative

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Listed:
  • Daniel Strech
  • Tracey Weissgerber
  • Ulrich Dirnagl
  • on behalf of QUEST Group

Abstract

The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples of scientists, journals, and funding agencies adopting responsible research practices. The QUEST (Quality-Ethics-Open Science-Translation) Center offers a unique opportunity to examine the role of institutions. The Berlin Institute of Health founded QUEST to increase the likelihood that research conducted at this large academic medical center would be trustworthy, useful for scientists and society, and ethical. QUEST researchers perform “science of science” studies to understand problems with standard practices and develop targeted solutions. The staff work with institutional leadership and local scientists to incentivize and support responsible practices in research, funding, and hiring. Some activities described in this paper focus on the institution, whereas others may benefit the national and international scientific community. Our experience, approaches, and recommendations will be informative for faculty leadership, administrators, and researchers interested in improving scientific practice.This Community Page article describes an ongoing large-scale structured initiative at the Berlin Institute of Health which aims at improving the robustness, reproducibility and transparency of research in an academic biomedical setting.

Suggested Citation

  • Daniel Strech & Tracey Weissgerber & Ulrich Dirnagl & on behalf of QUEST Group, 2020. "Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative," PLOS Biology, Public Library of Science, vol. 18(2), pages 1-9, February.
    • Handle: RePEc:plo:pbio00:3000576
    DOI: 10.1371/journal.pbio.3000576
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    References listed on IDEAS

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    1. Ulrich Dirnagl & Ingo Przesdzing & Claudia Kurreck & Sebastian Major, 2016. "A Laboratory Critical Incident and Error Reporting System for Experimental Biomedicine," PLOS Biology, Public Library of Science, vol. 14(12), pages 1-8, December.
    2. Ulf Toelch & Dirk Ostwald, 2018. "Digital open science—Teaching digital tools for reproducible and transparent research," PLOS Biology, Public Library of Science, vol. 16(7), pages 1-11, July.
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