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Standards for Cell Line Authentication and Beyond

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  • Jamie L Almeida
  • Kenneth D Cole
  • Anne L Plant

Abstract

Different genomic technologies have been applied to cell line authentication, but only one method (short tandem repeat [STR] profiling) has been the subject of a comprehensive and definitive standard (ASN-0002). Here we discuss the power of this document and why standards such as this are so critical for establishing the consensus technical criteria and practices that can enable progress in the fields of research that use cell lines. We also examine other methods that could be used for authentication and discuss how a combination of methods could be used in a holistic fashion to assess various critical aspects of the quality of cell lines.While definitive methods for human cell line authentication have been compiled in a documentary standard, this Perspective maintains that more research is required to provide similar vetting of methods for non-human cell lines.

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  • Jamie L Almeida & Kenneth D Cole & Anne L Plant, 2016. "Standards for Cell Line Authentication and Beyond," PLOS Biology, Public Library of Science, vol. 14(6), pages 1-9, June.
    • Handle: RePEc:plo:pbio00:1002476
    DOI: 10.1371/journal.pbio.1002476
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