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Can Nutrition or Inflammation Moderate the Age-Cognition Association Among Older Adults?

Author

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  • Elizabeth P Handing
  • Brent J Small
  • Ross Andel
  • Cathy L McEvoy
  • Nagi Kumar

Abstract

Objectives Previous research has shown that nutrition can influence cognitive abilities in older adults. We examined whether nutritional factors or inflammatory biomarkers moderate the age-cognition association. Method Analyses included 1,308 participants (age ≥60) from the National Health and Nutrition Examination Survey III. Macronutrients (% of calories from fat, protein, and carbohydrates), micronutrients/amino acids (blood serum values: Vitamins B12, C, D, E, folate, iron, homocysteine, and β-carotene), and inflammatory biomarkers (serum C-reactive protein, plasma fibrinogen, and serum ferritin) were examined as moderators with cognition. Cognition was measured by six tasks: immediate and delayed story recall, immediate and delayed word memory, digit subtraction, and questions about place/orientation. Results Higher values of serum folate were significantly associated with better cognitive scores. Specifically, the interaction between age-cognition and folate indicated the associations of higher age and lower global cognition and lower immediate story recall were weaker in those with higher folate values (p’s < .05). A significant interaction between age and plasma fibrinogen indicated that the association between age and worse digit subtraction was stronger with values >3.1 g/L. Discussion Folate and fibrinogen were significant moderators between age and cognition. Further research into the relationship between nutrition, inflammation, and cognitive aging is needed.

Suggested Citation

  • Elizabeth P Handing & Brent J Small & Ross Andel & Cathy L McEvoy & Nagi Kumar, 2019. "Can Nutrition or Inflammation Moderate the Age-Cognition Association Among Older Adults?," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 74(2), pages 193-201.
    • Handle: RePEc:oup:geronb:v:74:y:2019:i:2:p:193-201.
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    File URL: http://hdl.handle.net/10.1093/geronb/gbx054
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    References listed on IDEAS

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    1. Brent J. Small & Roger A. Dixon & John J. McArdle, 2011. "Tracking Cognition--Health Changes From 55 to 95 Years of Age," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 66(suppl_1), pages 153-161.
    2. Palmer Johnson & Leo Fay, 1950. "The Johnson-Neyman technique, its theory and application," Psychometrika, Springer;The Psychometric Society, vol. 15(4), pages 349-367, December.
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