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Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study

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Listed:
  • Correne A. DeCarlo
  • Stuart W. S. MacDonald
  • David Vergote
  • Jack Jhamandas
  • David Westaway
  • Roger A. Dixon

Abstract

Objectives. Mild cognitive impairment (MCI) is a high-risk condition for progression to Alzheimer’s disease (AD). Vascular health is a key mechanism underlying age-related cognitive decline and neurodegeneration. AD-related genetic risk factors may be associated with preclinical cognitive status changes. We examine independent and cross-domain interactive effects of vascular and genetic markers for predicting MCI status and stability.

Suggested Citation

  • Correne A. DeCarlo & Stuart W. S. MacDonald & David Vergote & Jack Jhamandas & David Westaway & Roger A. Dixon, 2016. "Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 71(6), pages 1004-1014.
    • Handle: RePEc:oup:geronb:v:71:y:2016:i:6:p:1004-1014.
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    File URL: http://hdl.handle.net/10.1093/geronb/gbv043
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