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Reduced Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor Is Associated With Cognitive Impairment in Late-Life Major Depression

Author

Listed:
  • Breno S. Diniz
  • Antonio L. Teixeira
  • Rodrigo Machado-Vieira
  • Leda L. Talib
  • Marcia Radanovic
  • Wagner F. Gattaz
  • Orestes V. Forlenza

Abstract

Objectives. Late-life depression (LLD) is associated with reduced neurotrophic support and abnormalities in neurodegenerative cascades. The aim of the present study is to determine the concentrations of brain-derived neurotrophic factor (BDNF), amyloid-β42, total Tau, and phosphorylated Tau in the cerebrospinal fluid (CSF) of patients with LLD and cognitive impairment compared to healthy older adults.

Suggested Citation

  • Breno S. Diniz & Antonio L. Teixeira & Rodrigo Machado-Vieira & Leda L. Talib & Marcia Radanovic & Wagner F. Gattaz & Orestes V. Forlenza, 2014. "Reduced Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor Is Associated With Cognitive Impairment in Late-Life Major Depression," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 69(6), pages 845-851.
    • Handle: RePEc:oup:geronb:v:69:y:2014:i:6:p:845-851.
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    File URL: http://hdl.handle.net/10.1093/geronb/gbu096
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