IDEAS home Printed from https://ideas.repec.org/a/oup/biomet/v97y2010i1p246-253.html
   My bibliography  Save this article

The distribution-based p-value for the outlier sum in differential gene expression analysis

Author

Listed:
  • Lin-An Chen
  • Dung-Tsa Chen
  • Wenyaw Chan

Abstract

Outlier sums were proposed by Tibshirani & Hastie (2007) and Wu (2007) for detecting outlier genes where only a small subset of disease samples shows unusually high gene expression, but they did not develop their distributional properties and formal statistical inference. In this study, a new outlier sum for detection of outlier genes is proposed, its asymptotic distribution theory is developed, and the p-value based on this outlier sum is formulated. Its analytic form is derived on the basis of the large-sample theory. We compare the proposed method with existing outlier sum methods by power comparisons. Our method is applied to DNA microarray data from samples of primary breast tumors examined by Huang et al. (2003). The results show that the proposed method is more efficient in detecting outlier genes. Copyright 2010, Oxford University Press.

Suggested Citation

  • Lin-An Chen & Dung-Tsa Chen & Wenyaw Chan, 2010. "The distribution-based p-value for the outlier sum in differential gene expression analysis," Biometrika, Biometrika Trust, vol. 97(1), pages 246-253.
    • Handle: RePEc:oup:biomet:v:97:y:2010:i:1:p:246-253
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1093/biomet/asp075
    Download Restriction: Access to full text is restricted to subscribers.
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hung-Chia Chen & James J. Chen, 2016. "Hybrid Mixture Model for Subpopulation Identification," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 8(1), pages 28-42, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:oup:biomet:v:97:y:2010:i:1:p:246-253. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Oxford University Press (email available below). General contact details of provider: https://academic.oup.com/biomet .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.