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Simultaneous discovery of rare and common segment variants

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  • X. Jessie Jeng
  • T. Tony Cai
  • Hongzhe Li

Abstract

Copy number variant is an important type of genetic structural variation appearing in germline DNA, ranging from common to rare in a population. Both rare and common copy number variants have been reported to be associated with complex diseases, so it is important to identify both simultaneously based on a large set of population samples. We develop a proportion adaptive segment selection procedure that automatically adjusts to the unknown proportions of the carriers of the segment variants. We characterize the detection boundary that separates the region where a segment variant is detectable by some method from the region where it cannot be detected. Although the detection boundaries are very different for the rare and common segment variants, it is shown that the proposed procedure can reliably identify both whenever they are detectable. Compared with methods for single-sample analysis, this procedure gains power by pooling information from multiple samples. The method is applied to analyse neuroblastoma samples and identifies a large number of copy number variants that are missed by single-sample methods. Copyright 2013, Oxford University Press.

Suggested Citation

  • X. Jessie Jeng & T. Tony Cai & Hongzhe Li, 2013. "Simultaneous discovery of rare and common segment variants," Biometrika, Biometrika Trust, vol. 100(1), pages 157-172.
  • Handle: RePEc:oup:biomet:v:100:y:2013:i:1:p:157-172
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    File URL: http://hdl.handle.net/10.1093/biomet/ass059
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    Cited by:

    1. Xinge Jessie Jeng & Zhongyin John Daye & Wenbin Lu & Jung-Ying Tzeng, 2016. "Rare Variants Association Analysis in Large-Scale Sequencing Studies at the Single Locus Level," PLOS Computational Biology, Public Library of Science, vol. 12(6), pages 1-23, June.
    2. Stefan Richter & Weining Wang & Wei Biao Wu, 2023. "Testing for parameter change epochs in GARCH time series," The Econometrics Journal, Royal Economic Society, vol. 26(3), pages 467-491.

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