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Reinventing type 2 immunity in cancer

Author

Listed:
  • Marek Wagner

    (Łukasiewicz Research Network–PORT Polish Center for Technology Development)

  • Hiroyoshi Nishikawa

    (Nagoya University Graduate School of Medicine
    National Cancer Center)

  • Shigeo Koyasu

    (RIKEN Center for Integrative Medical Sciences
    National Institutes for Quantum Science and Technology (QST))

Abstract

Our understanding of type 2 immunity has undergone a substantial transformation in recent years, revealing previously unknown functions. Beyond its canonical role in defence against parasitic helminth infections, type 2 immunity safeguards the host through additional mechanisms, including the suppression of excessive type 1 immune responses, regulation of tissue repair and maintenance of adipose tissue homeostasis. However, unlike type 1 immune responses, type 2 immunity is perceived as a potential promoter of tumorigenesis. Emerging evidence challenges this perspective, painting a more nuanced picture in which type 2 immunity might protect against or even actively suppress tumour growth and progression. In this Review, we explore discoveries that highlight the potential of type 2 immunity in reshaping the landscape of cancer immunotherapies.

Suggested Citation

  • Marek Wagner & Hiroyoshi Nishikawa & Shigeo Koyasu, 2025. "Reinventing type 2 immunity in cancer," Nature, Nature, vol. 637(8045), pages 296-303, January.
    • Handle: RePEc:nat:nature:v:637:y:2025:i:8045:d:10.1038_s41586-024-08194-2
    DOI: 10.1038/s41586-024-08194-2
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