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π-HuB: the proteomic navigator of the human body

Author

Listed:
  • Fuchu He

    (Beijing Institute of Lifeomics
    International Academy of Phronesis Medicine (Guangdong))

  • Ruedi Aebersold

    (ETH Zurich)

  • Mark S. Baker

    (Macquarie University)

  • Xiuwu Bian

    (Ministry of Education of China)

  • Xiaochen Bo

    (Institute of Health Service and Transfusion Medicine)

  • Daniel W. Chan

    (Johns Hopkins University)

  • Cheng Chang

    (Beijing Institute of Lifeomics)

  • Luonan Chen

    (Chinese Academy of Sciences)

  • Xiangmei Chen

    (Beijing Key Laboratory of Kidney Disease Research)

  • Yu-Ju Chen

    (Academia Sinica)

  • Heping Cheng

    (Peking University)

  • Ben C. Collins

    (Queen’s University of Belfast)

  • Fernando Corrales

    (Centro Nacional de Biotecnología-CSIC)

  • Jürgen Cox

    (Max-Planck Institute of Biochemistry)

  • Weinan E

    (AI for Science Institute
    Peking University)

  • Jennifer E. Van Eyk

    (Cedars Sinai Medical Center)

  • Jia Fan

    (Fudan University)

  • Pouya Faridi

    (Hudson Institute of Medical Research
    Monash University)

  • Daniel Figeys

    (University of Ottawa)

  • George Fu Gao

    (Zhejiang University)

  • Wen Gao

    (Pengcheng Laboratory
    Peking University)

  • Zu-Hua Gao

    (University of British Columbia)

  • Keisuke Goda

    (University of Tokyo
    University of California
    Wuhan University)

  • Wilson Wen Bin Goh

    (Nanyang Technological University)

  • Dongfeng Gu

    (Southern University of Science and Technology)

  • Changjiang Guo

    (Tianjin Institute of Environmental and Operational Medicine)

  • Tiannan Guo

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake University)

  • Yuezhong He

    (International Academy of Phronesis Medicine (Guangdong))

  • Albert J. R. Heck

    (University of Utrecht
    Netherlands Proteomics Center)

  • Henning Hermjakob

    (European Bioinformatics Institute (EMBL-EBI))

  • Tony Hunter

    (Salk Institute for Biological Studies)

  • Narayanan Gopalakrishna Iyer

    (National Cancer Centre Singapore)

  • Ying Jiang

    (Beijing Institute of Lifeomics)

  • Connie R. Jimenez

    (Amsterdam UMC)

  • Lokesh Joshi

    (University of Galway)

  • Neil L. Kelleher

    (Northwestern University)

  • Ming Li

    (University of Waterloo
    Central China Institute of Artificial Intelligence)

  • Yang Li

    (Beijing Institute of Lifeomics)

  • Qingsong Lin

    (National University of Singapore)

  • Cui Hua Liu

    (Chinese Academy of Sciences)

  • Fan Liu

    (Leibniz-Forschungsinstitut für MolekularePharmakologie (FMP))

  • Guang-Hui Liu

    (Chinese Academy of Sciences)

  • Yansheng Liu

    (Yale University School of Medicine)

  • Zhihua Liu

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Teck Yew Low

    (Universiti Kebangsaan Malaysia)

  • Ben Lu

    (Central South University)

  • Matthias Mann

    (Max Planck Institute of Biochemistry)

  • Anming Meng

    (Tsinghua-Peking Center for Life Sciences)

  • Robert L. Moritz

    (Institute for Systems Biology)

  • Edouard Nice

    (Monash University)

  • Guang Ning

    (Shanghai Jiao Tong University School of Medicine
    Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China
    Shanghai Jiao Tong University School of Medicine)

  • Gilbert S. Omenn

    (University of Michigan)

  • Christopher M. Overall

    (University of British Columbia
    Yonsei University)

  • Giuseppe Palmisano

    (University of São Paulo)

  • Yaojin Peng

    (Chinese Academy of Sciences
    Beijing Institute for Stem Cell and Regenerative Medicine
    University of the Chinese Academy of Sciences)

  • Charles Pineau

    (Univ. Rennes, Inserm, EHESP, Irset)

  • Terence Chuen Wai Poon

    (University of Macau)

  • Anthony W. Purcell

    (Monash University)

  • Jie Qiao

    (Peking University Third Hospital)

  • Roger R. Reddel

    (The University of Sydney)

  • Phillip J. Robinson

    (The University of Sydney)

  • Paola Roncada

    (University Magna Græcia of Catanzaro)

  • Chris Sander

    (Harvard Medical School
    Broad Institute of MIT and Harvard)

  • Jiahao Sha

    (Nanjing Medical University)

  • Erwei Song

    (Sun Yat-Sen University
    Sun Yat-Sen University)

  • Sanjeeva Srivastava

    (Indian Institute of Technology Bombay)

  • Aihua Sun

    (Beijing Institute of Lifeomics)

  • Siu Kwan Sze

    (Brock University)

  • Chao Tang

    (Peking University)

  • Liujun Tang

    (Beijing Institute of Lifeomics)

  • Ruijun Tian

    (Southern University of Science and Technology)

  • Juan Antonio Vizcaíno

    (European Bioinformatics Institute (EMBL-EBI))

  • Chanjuan Wang

    (Beijing Institute of Lifeomics)

  • Chen Wang

    (Peking Union Medical College
    China-Japan Friendship Hospital)

  • Xiaowen Wang

    (Beijing Institute of Lifeomics)

  • Xinxing Wang

    (Tianjin Institute of Environmental and Operational Medicine)

  • Yan Wang

    (Beijing Institute of Lifeomics)

  • Tobias Weiss

    (University Hospital Zurich and University of Zurich)

  • Mathias Wilhelm

    (Technical University of Munich)

  • Robert Winkler

    (Center for Research and Advanced Studies)

  • Bernd Wollscheid

    (ETH Zurich)

  • Limsoon Wong

    (National University of Singapore
    National University of Singapore)

  • Linhai Xie

    (Beijing Institute of Lifeomics)

  • Wei Xie

    (Tsinghua-Peking Center for Life Sciences)

  • Tao Xu

    (Guangzhou National Laboratory
    Guangzhou Medical University)

  • Tianhao Xu

    (International Academy of Phronesis Medicine (Guangdong))

  • Liying Yan

    (Peking University Third Hospital)

  • Jing Yang

    (Guangzhou National Laboratory)

  • Xiao Yang

    (Beijing Institute of Lifeomics)

  • John Yates

    (The Scripps Research Institute)

  • Tao Yun

    (China Science and Technology Exchange Center)

  • Qiwei Zhai

    (Chinese Academy of Sciences)

  • Bing Zhang

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Hui Zhang

    (Johns Hopkins School of Medicine)

  • Lihua Zhang

    (Chinese Academy of Sciences)

  • Lingqiang Zhang

    (Beijing Institute of Lifeomics)

  • Pingwen Zhang

    (Peking University
    Wuhan University)

  • Yukui Zhang

    (Chinese Academy of Sciences)

  • Yu Zi Zheng

    (International Academy of Phronesis Medicine (Guangdong)
    University of British Columbia)

  • Qing Zhong

    (The University of Sydney)

  • Yunping Zhu

    (Beijing Institute of Lifeomics)

Abstract

The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual’s body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies. Recent advances in proteomic technology and computational sciences now provide opportunities to investigate the intricate biology of the human body at unprecedented resolution and scale. Here we introduce a big-science endeavour called π-HuB (proteomic navigator of the human body). The aim of the π-HuB project is to (1) generate and harness multimodality proteomic datasets to enhance our understanding of human biology; (2) facilitate disease risk assessment and diagnosis; (3) uncover new drug targets; (4) optimize appropriate therapeutic strategies; and (5) enable intelligent healthcare, thereby ushering in a new era of proteomics-driven phronesis medicine. This ambitious mission will be implemented by an international collaborative force of multidisciplinary research teams worldwide across academic, industrial and government sectors.

Suggested Citation

  • Fuchu He & Ruedi Aebersold & Mark S. Baker & Xiuwu Bian & Xiaochen Bo & Daniel W. Chan & Cheng Chang & Luonan Chen & Xiangmei Chen & Yu-Ju Chen & Heping Cheng & Ben C. Collins & Fernando Corrales & Jü, 2024. "π-HuB: the proteomic navigator of the human body," Nature, Nature, vol. 636(8042), pages 322-331, December.
    • Handle: RePEc:nat:nature:v:636:y:2024:i:8042:d:10.1038_s41586-024-08280-5
    DOI: 10.1038/s41586-024-08280-5
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