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Minute-scale oscillatory sequences in medial entorhinal cortex

Author

Listed:
  • Soledad Gonzalo Cogno

    (Norwegian University of Science and Technology)

  • Horst A. Obenhaus

    (Norwegian University of Science and Technology)

  • Ane Lautrup

    (Norwegian University of Science and Technology)

  • R. Irene Jacobsen

    (Norwegian University of Science and Technology)

  • Claudia Clopath

    (Imperial College London)

  • Sebastian O. Andersson

    (Norwegian University of Science and Technology
    Max Planck Institute for Brain Research)

  • Flavio Donato

    (Norwegian University of Science and Technology
    Biozentrum Universität Basel)

  • May-Britt Moser

    (Norwegian University of Science and Technology)

  • Edvard I. Moser

    (Norwegian University of Science and Technology)

Abstract

The medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity to be organized across long durations of experience1. Whereas location is known to be encoded by spatially tuned cell types in this brain region2,3, little is known about how the activity of entorhinal cells is tied together over time at behaviourally relevant time scales, in the second-to-minute regime. Here we show that MEC neuronal activity has the capacity to be organized into ultraslow oscillations, with periods ranging from tens of seconds to minutes. During these oscillations, the activity is further organized into periodic sequences. Oscillatory sequences manifested while mice ran at free pace on a rotating wheel in darkness, with no change in location or running direction and no scheduled rewards. The sequences involved nearly the entire cell population, and transcended epochs of immobility. Similar sequences were not observed in neighbouring parasubiculum or in visual cortex. Ultraslow oscillatory sequences in MEC may have the potential to couple neurons and circuits across extended time scales and serve as a template for new sequence formation during navigation and episodic memory formation.

Suggested Citation

  • Soledad Gonzalo Cogno & Horst A. Obenhaus & Ane Lautrup & R. Irene Jacobsen & Claudia Clopath & Sebastian O. Andersson & Flavio Donato & May-Britt Moser & Edvard I. Moser, 2024. "Minute-scale oscillatory sequences in medial entorhinal cortex," Nature, Nature, vol. 625(7994), pages 338-344, January.
  • Handle: RePEc:nat:nature:v:625:y:2024:i:7994:d:10.1038_s41586-023-06864-1
    DOI: 10.1038/s41586-023-06864-1
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    Cited by:

    1. Erik Hermansen & David A. Klindt & Benjamin A. Dunn, 2024. "Uncovering 2-D toroidal representations in grid cell ensemble activity during 1-D behavior," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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