Author
Listed:
- Sankaraleengam Alagapan
(Georgia Institute of Technology)
- Ki Sueng Choi
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Stephen Heisig
(Icahn School of Medicine at Mount Sinai)
- Patricio Riva-Posse
(Emory University School of Medicine)
- Andrea Crowell
(Emory University School of Medicine)
- Vineet Tiruvadi
(Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University
Emory University School of Medicine)
- Mosadoluwa Obatusin
(Icahn School of Medicine at Mount Sinai)
- Ashan Veerakumar
(Schulich School of Medicine and Dentistry at Western University)
- Allison C. Waters
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Robert E. Gross
(Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University
Emory University School of Medicine
Emory University School of Medicine)
- Sinead Quinn
(Emory University School of Medicine)
- Lydia Denison
(Emory University School of Medicine)
- Matthew O’Shaughnessy
(Georgia Institute of Technology)
- Marissa Connor
(Georgia Institute of Technology)
- Gregory Canal
(Georgia Institute of Technology)
- Jungho Cha
(Icahn School of Medicine at Mount Sinai)
- Rachel Hershenberg
(Emory University School of Medicine)
- Tanya Nauvel
(Icahn School of Medicine at Mount Sinai)
- Faical Isbaine
(Emory University School of Medicine)
- Muhammad Furqan Afzal
(Icahn School of Medicine at Mount Sinai)
- Martijn Figee
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Brian H. Kopell
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Robert Butera
(Georgia Institute of Technology
Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University)
- Helen S. Mayberg
(Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai)
- Christopher J. Rozell
(Georgia Institute of Technology)
Abstract
Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD)1. However, achieving stable recovery is unpredictable2, typically requiring trial-and-error stimulation adjustments due to individual recovery trajectories and subjective symptom reporting3. We currently lack objective brain-based biomarkers to guide clinical decisions by distinguishing natural transient mood fluctuations from situations requiring intervention. To address this gap, we used a new device enabling electrophysiology recording to deliver SCC DBS to ten TRD participants (ClinicalTrials.gov identifier NCT01984710). At the study endpoint of 24 weeks, 90% of participants demonstrated robust clinical response, and 70% achieved remission. Using SCC local field potentials available from six participants, we deployed an explainable artificial intelligence approach to identify SCC local field potential changes indicating the patient’s current clinical state. This biomarker is distinct from transient stimulation effects, sensitive to therapeutic adjustments and accurate at capturing individual recovery states. Variable recovery trajectories are predicted by the degree of preoperative damage to the structural integrity and functional connectivity within the targeted white matter treatment network, and are matched by objective facial expression changes detected using data-driven video analysis. Our results demonstrate the utility of objective biomarkers in the management of personalized SCC DBS and provide new insight into the relationship between multifaceted (functional, anatomical and behavioural) features of TRD pathology, motivating further research into causes of variability in depression treatment.
Suggested Citation
Sankaraleengam Alagapan & Ki Sueng Choi & Stephen Heisig & Patricio Riva-Posse & Andrea Crowell & Vineet Tiruvadi & Mosadoluwa Obatusin & Ashan Veerakumar & Allison C. Waters & Robert E. Gross & Sinea, 2023.
"Cingulate dynamics track depression recovery with deep brain stimulation,"
Nature, Nature, vol. 622(7981), pages 130-138, October.
Handle:
RePEc:nat:nature:v:622:y:2023:i:7981:d:10.1038_s41586-023-06541-3
DOI: 10.1038/s41586-023-06541-3
Download full text from publisher
As the access to this document is restricted, you may want to search for a different version of it.
Citations
Citations are extracted by the
CitEc Project, subscribe to its
RSS feed for this item.
Cited by:
- Jiayang Xiao & Joshua A. Adkinson & John Myers & Anusha B. Allawala & Raissa K. Mathura & Victoria Pirtle & Ricardo Najera & Nicole R. Provenza & Eleonora Bartoli & Andrew J. Watrous & Denise Oswalt &, 2024.
"Beta activity in human anterior cingulate cortex mediates reward biases,"
Nature Communications, Nature, vol. 15(1), pages 1-13, December.
- Yuhao Huang & Rina Zelmann & Peter Hadar & Jaquelin Dezha-Peralta & R. Mark Richardson & Ziv M. Williams & Sydney S. Cash & Corey J. Keller & Angelique C. Paulk, 2024.
"Theta-burst direct electrical stimulation remodels human brain networks,"
Nature Communications, Nature, vol. 15(1), pages 1-17, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:622:y:2023:i:7981:d:10.1038_s41586-023-06541-3. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.