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Immune sensing of food allergens promotes avoidance behaviour

Author

Listed:
  • Esther B. Florsheim

    (Yale University School of Medicine
    Arizona State University
    Arizona State University)

  • Nathaniel D. Bachtel

    (Yale University School of Medicine)

  • Jaime L. Cullen

    (Yale University School of Medicine)

  • Bruna G. C. Lima

    (Arizona State University
    University of São Paulo
    Yale University School of Medicine)

  • Mahdieh Godazgar

    (Yale University School of Medicine)

  • Fernando Carvalho

    (Yale University School of Medicine)

  • Carolina P. Chatain

    (Yale University School of Medicine)

  • Marcelo R. Zimmer

    (Yale University School of Medicine)

  • Cuiling Zhang

    (Yale University School of Medicine)

  • Gregory Gautier

    (Centre de Recherche sur l’Inflammation, INSERM UMR1149, CNRS EMR8252, Université Paris Cité)

  • Pierre Launay

    (Centre de Recherche sur l’Inflammation, INSERM UMR1149, CNRS EMR8252, Université Paris Cité)

  • Andrew Wang

    (Yale University School of Medicine
    Yale University School of Medicine)

  • Marcelo O. Dietrich

    (Yale University School of Medicine)

  • Ruslan Medzhitov

    (Yale University School of Medicine
    Howard Hughes Medical Institute
    Yale University School of Medicine)

Abstract

In addition to its canonical function of protection from pathogens, the immune system can also alter behaviour1,2. The scope and mechanisms of behavioural modifications by the immune system are not yet well understood. Here, using mouse models of food allergy, we show that allergic sensitization drives antigen-specific avoidance behaviour. Allergen ingestion activates brain areas involved in the response to aversive stimuli, including the nucleus of tractus solitarius, parabrachial nucleus and central amygdala. Allergen avoidance requires immunoglobulin E (IgE) antibodies and mast cells but precedes the development of gut allergic inflammation. The ability of allergen-specific IgE and mast cells to promote avoidance requires cysteinyl leukotrienes and growth and differentiation factor 15. Finally, a comparison of C57BL/6 and BALB/c mouse strains revealed a strong effect of the genetic background on the avoidance behaviour. These findings thus point to antigen-specific behavioural modifications that probably evolved to promote niche selection to avoid unfavourable environments.

Suggested Citation

  • Esther B. Florsheim & Nathaniel D. Bachtel & Jaime L. Cullen & Bruna G. C. Lima & Mahdieh Godazgar & Fernando Carvalho & Carolina P. Chatain & Marcelo R. Zimmer & Cuiling Zhang & Gregory Gautier & Pie, 2023. "Immune sensing of food allergens promotes avoidance behaviour," Nature, Nature, vol. 620(7974), pages 643-650, August.
    • Handle: RePEc:nat:nature:v:620:y:2023:i:7974:d:10.1038_s41586-023-06362-4
    DOI: 10.1038/s41586-023-06362-4
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    Cited by:

    1. Qingtao Sun & Daniëlle Lisdonk & Miriam Ferrer & Bruno Gegenhuber & Melody Wu & Youngkyu Park & David A. Tuveson & Jessica Tollkuhn & Tobias Janowitz & Bo Li, 2024. "Area postrema neurons mediate interleukin-6 function in cancer cachexia," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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